http://science.sciencemag.org/content/sci/201/4359/899.2.full.pdf

Phenomenology of perception.

In Art as Experience, Dewey brings together the deep and enduring connection between art and human experience. Art is understood not as a commodity or solitary object but as an intensely meaningful...

Art as experience

Pandora's Hope. Essays on the Reality of Science Studies, by Bruno Latour. Cambridge, MA, London, UK: Harvard University Press, 1999.

From brushing our teeth first thing in the morning to turning off the bedside lamp last thing at night, the human hand—all would agree—is indispensable, not just for everything we do but for those artifacts with which we do them. Every single drop of human culture, from the stunning paintings in the Chauvet caves of thirty thousand years ago to my writing these words, via every dwelling, temple and cathedral ever built, every piece of jewellery that adorned the human body, every musical instrument to have plucked the human soul, was created by the human hand. And we have the hand, too, to thank for our history, for without it our past would have just slipped away unrecorded into the dark abyss of time.

These achievements of the human hand are obvious enough if we bother to reflect on them, which we rarely do for, as St Augustine observed in his Confessions: ‘While men go abroad to wonder at the height of mountains, the vast compass of the oceans, the circular motion of the stars... yet they pass by themselves without wondering’. It would be an easy summary of Raymond Tallis's book to say that he seeks to reawaken that sense of wonder at ourselves by extolling the marvellous attributes of the hand—which indeed he does, and very effectively too. But Tallis has further ambitions. He is, as those who are acquainted with his previous writings will know, a doughty warrior against the false certainties of our age. The lack of recognition of the hand's unique attributes is, he points out, no mere oversight. Rather it is a necessary consequence of the prevailing scientific ideology—exemplified by the writings of E O Wilson, R Dawkins, D Dennett, et al.—who insist, as of principle, that there can be nothing exceptional about humanity. We are, are we not, nothing but naked apes. Hence, the vast gulf that separates the aptitudes of our hands and those of our nearest cousins—whose cleverest manipulative wheeze is to crack a nut with a stone—can still only ever be one of degree, never of kind. Professor Tallis sets out to show how it is not so.

The success of the human hand lies in its incorporation of three quite distinct attributes into one single structure; it is not just an organ of manipulation, but also an organ of knowledge and communication. The hand acts, it knows, and it speaks. As for the first of these, Tallis draws attention to the remarkable specifications that allow the hand to encompass the two contradictory functions of being both an instrument of great power and yet at the same time one of breathtaking precision. The hand that can hammer, thrust, grasp and crush is the same hand that can thread a needle, play a flute and insert a pipette a fraction of a millimetre in diameter into the axon of a squid. The hand could do none of these things were it not for the second attribute, as an organ of knowledge which through the sense of touch comprehends and explores the external world. This cognitive hand is staggeringly sensitive; just one tap of the fingernail can distinguish between paper, fibre, wood, plastic and steel. It can ‘see’ in the dark and, being at the end of a long highly flexible limb, can also ‘see’ round corners, interrogating objects not just to determine what they are but as a preliminary to action. And as if that were not enough, there is the hand as organ of communication, complementing the voice by conveying all those feelings and emotions that lie beyond words: the hand touches, pets, strokes and caresses, conveying both comforting affection and sexual desire. From here Tallis takes us on a breathtaking tour of the specific attributes of the digits one by one—the stompy opposable thumb that has made us lords of all creation; the index finger that both instructs and admonishes; the middle finger both ‘impudicus’ and stakhanovite of the power grip. Then it is time to move on to the specific attributes of the digits when they dance together in combinations of two, three, four, five or ten—each with its own special talent. And then there is the talking hand, the playful hand, the numerate hand and still its possibilities are not exhausted.

To be sure, the hands of our primate cousins possess similar attributes, albeit in attenuated form: they too can manipulate, learn of the world through touch and express affection by grooming. But why then can the human hand do so much more? It cannot be simply a matter of biology: rather, the human hand must have crossed some sort of metaphysical rubicon to leave our primate cousins far behind on its distant bank—and that rubicon, Tallis suggests, is the ability to make ‘infinite use of finite resources’. The human hand does not merely possess a wide range of grips; it is capable of a limitlessly varied range of grips each of which can be customized to the needs of the moment. Self-evidently, the anatomical differences between the human and primate hands cannot explain the gulf in achievement; rather, as Tallis points out, we should look at ‘what further differences are progressively created out of that difference’.

This liberation from the dead hand (as it were) of evolutionary determinism frees us to contemplate and appreciate the human hand for what it is and does. Tallis conjures up a challenging and endlessly fascinating way of thinking about ourselves that should act as a signpost for the future where we might learn once again to glimpse, as our forebears did, the wonder—and mystery—of ourselves.

https://jrs.sagepub.com/content/97/4/201.full.pdf

The Hand: a Philosophical Inquiry into Human Being:

This paper, drawing on research from the ‘HANDMADE - Understanding Creative Gesture in Pottery Making’ project (sponsored by the ERC), will attempt to show how a focus on the temporality of touch and the tactility of making can help us disambiguate the often discussed, but little understood, dialogue between maker and material. Our main thesis is that with increasing levels of skill, tactile perception plays an active role in transforming a mere kinetic interaction (where potter and clay are causally coupled) into a multi-modal kinaesthetic transaction (where the potter becomes attentive to the expressive affordances of clay and recursively the clay becomes responsive to the creative affordances of the potter’s hand). We call this situational attunement between the potter and clay haptic attentive unity (HAU). The primary objective of this paper is to explore the links between touch and attentive engagement in the context of pottery making and use the notion of HAU to account for the dialogic character of creative material engagement.

https://journals.sagepub.com/doi/pdf/10.1177/26349795221109231

Where the touching is touched: The role of haptic attentive unity in the dialogue between maker and material

In a context where fashion design and retail activities are increasingly transferring to the digital environment, mediating touch has become a matter of concern for the field. However, as literature shows, articulating our sensory experiences with materials is a challenging task. This position paper explores the experiential knowledge observed through embodied design processes. This is done by analysing our diverse approaches to introduce tools that help designers to understand people’s perceptual experience with textile materials. We build on our previous research that identified relevant embodied processes to textile selection, and reflect on how we have explored how sensing technology can augment and empower each of these processes, thereby supporting design. We conclude by discussing the learning outcomes of analysing such tools, in order to reflect on the future of our research applied to the digital realm.

Radically Relational Tools: A Design Framework to Explore Materials through Embodied Processes


 Oncolytic virotherapy represents a promising therapeutic strategy for cancers that do not respond well to immune checkpoint inhibitors. Oncolytic viruses (OV) preferentially replicate in and lyse tumor cells, leading to systemic immune stimulation. Studies have shown that hypersialylation promotes tumor growth and metastasis, as well as the suppression of immune cells. Cancer-associated fibroblasts (CAFs) are known to facilitate tumor invasion and angiogenesis and maintain immunosuppressive microenvironment in solid tumors. We are developing vvDD-Sial-FAP/CD3, an oncolytic vaccinia virus expressing a membrane-bound sialidase, to remove sialic acids from the cell surface glycans, and fibroblast activation protein (FAP)-targeted T cell engager, to eliminate glycoimmune checkpoint and tumor stroma, respectively. vvDD-Sial-FAP/CD3 is an engineered vaccinia virus of Western Reserve (WR) strain with: (1) an insertional disruption of the viral thymidine kinase (TK) gene with the sialidase and FAP/CD3 transgenes. TK is an essential enzyme for the pyrimidine synthesis pathway; viral TK gene deletion thus results in selective replication of virus in rapidly dividing cancerous cells with high intracellular nucleotide pools, and (2) a deletion of the vaccinia growth factor (VGF) genes for greater dependence on the cell cycling status of the cancer cells. Our results showed that sialidase expressed from vvDD-Sial-FAP/CD3 efficiently cleaves the sialic acids from the cell surface and the Fc fused to the sialidase induced antibody-dependent cell-mediated cytotoxicity (ADCC) using an ADCC reporter assay. In vitro efficacy studies were conducted using HCT-116 human colon cancer cells mixed with FAP-expressing normal human dermal fibroblasts or FAP-positive HCC1143 human breast cancer cells in the presence of human peripheral blood mononuclear cells. In both tumor models, vvDD-Sial-FAP/CD3 induced activation of both CD4+ and CD8+ T cells, as measured by the upregulation of CD69 and CD25 markers and increased granzyme B release, which resulted in enhanced cell killing. Using A549 co-cultured with CAFs microtissues, we showed that vvDD-Sial-FAP/CD3 spread efficiently within the tumor spheroids. In addition, vvDD-Sial-FAP/CD3 increased tumor-infiltrated lymphocytes, leading to enhanced cell killing. Taken together, our results have demonstrated potent anti-tumor and -stroma effects induced by vvDD-Sial-FAP/CD3 in multiple cancer models. In vivo efficacy of vvDD-Sial-FAP/CD3, either alone or in combination with checkpoint inhibitor or NK cell therapy, is being evaluated.
 Citation Format: Winnie M. Chan, Mariya Viskovska, Micaela McArthur, Xue Mary Yu, Wei Liang, Zane Norman, Xiaotong Song, Nancy T. Chang, Haiyan Jiang. Glycoimmune checkpoint and tumor stroma-targeted oncolytic vaccinia virus for the treatment of solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3300.

Abstract 3300: Glycoimmune checkpoint and tumor stroma-targeted oncolytic vaccinia virus for the treatment of solid tumors

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Radically Relational Tools: A Design Framework to Explore Materials through Embodied Processes

Abstract 3300: Glycoimmune checkpoint and tumor stroma-targeted oncolytic vaccinia virus for the treatment of solid tumors