Xue He
Central South University
15 Papers
8 Citations
Xue He is an academic researcher from Central South University. The author has contributed to research in topics: Apoptosis & Medicine. The author has an hindex of 4, co-authored 10 publications.
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Papers
Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model
TL;DR: Cigarette-induced oxidative stress mediates pulmonary apoptosis and hypermethylation of the Bcl-2 promoter in emphysema models through DNMT1.
The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells
TL;DR: It is proved that HBO1 could reverse the apoptosis of HBECs induced by CSE and promoted the expression of anti-apoptotic BCL-2 protein and enhanced H3K14 acetylation in airway epithelial cells.
DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell
Zihang Zeng,Tiao Li,Xiangming Liu,Yiming Ma,Lijuan Luo,Zuli Wang,Zhiqi Zhao,Herui Li,Xue He,Huihui Zeng,Yongguang Tao,Yan Chen +11 more
TL;DR: It is found that TET2 regulates CS induced lipid peroxidation through demethylating glutathione peroxidase 4 (GPx4), thus alleviating airway epithelial cell ferroptosis in COPD.
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The protective effect of PRMT6 overexpression on cigarette smoke extract-induced murine emphysema model
Xue He,Tiao Li,Naixin Kang,Huihui Zeng,Siying Ren,Dandan Zong,Jinhua Li,Shan Cai,Ping Chen,Yan Chen +9 more
TL;DR: The expression of PRMT6 was significantly downregulated in the pulmonary parenchyma in smokers with COPD as well as in mice treated with CSE, which might inhibit inflammation, apoptosis, and oxidative stress in CSE-induced emphysema mediated by H3R2me2a.
F-Box Protein FBXW17-Mediated Proteasomal Degradation of Protein Methyltransferase PRMT6 Exaggerates CSE-Induced Lung Epithelial Inflammation and Apoptosis.
TL;DR: In this article, a histone methyl modifier, protein arginine N-methyltransferase 6 (PRMT6), is reported to alleviate cigarette smoke extract (CSE)-induced emphysema through inhibiting inflammation and cell apoptosis.