Xu Wang
Boston Children's Hospital
15 Papers
22 Citations
Xu Wang is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Gene mutation & Exome sequencing. The author has an hindex of 7, co-authored 12 publications.
Chat about Author
Papers
TSGA10 is a novel candidate gene associated with acephalic spermatozoa.
Yanwei Sha,Yan-Kun Sha,Zhi-Yong Ji,Libin Mei,Lu Ding,Qing Zhang,Ping-Ping Qiu,Shaobin Lin,Xu Wang,Ping Li,Xiaohui Xu,Lin Li +11 more
TL;DR: A 27 years old infertile male from a consanguineous family, who presented with 99% headless sperm in his ejaculate is reported, suggesting the presence of rare sequence variants within TSGA10 may be associated with acephalic spermatozoa in humans.
92
A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review
Yanwei Sha,Liang-Kai Zheng,Zhi-Yong Ji,Libin Mei,Lu Ding,Shaobin Lin,Xu Wang,Xiaoyu Yang,Ping Li +8 more
TL;DR: This study and previous literature indicate that TEX11 mutations are closely associated with male infertility, especially azoospermia, although auxiliary clinical analyses are needed to figure out the causes of male infertility.
Genetic contribution of SUN5 mutations to acephalic spermatozoa in Fujian China.
Yanwei Sha,Xiaohui Xu,Zhi-Yong Ji,Shaobin Lin,Xu Wang,Ping-Ping Qiu,Yulin Zhou,Libin Mei,Zhi-Ying Su,Lin Li,Ping Li +10 more
TL;DR: The study suggests that the contribution of SUN5 mutations to acephalic spermatozoa might not be as high as described previously, and these results will help in the genetic counseling of patients with acephalo-somatica.
46
A novel mutation in HAUS7 results in severe oligozoospermia in two brothers.
Lin Li,Yanwei Sha,Zhi-Ying Su,Libin Mei,Zhi-Yong Ji,Qing Zhang,Shaobin Lin,Xu Wang,Ping-Ping Qiu,Ping Li,Chenghong Yin +10 more
TL;DR: WES identified a hemizygous variant in HAUS7 (c.G386T:p.G129V), an X-linked gene reported to play a role in the meiotic maturation and chromosome alignment of germ cells, which may be associated with severe oligozoospermia.
17
A successful pregnancy by intracytoplasmic sperm injection using ejaculate sperm from an infertile man with 46, XX/46, XY true hermaphrodite.
TL;DR: The patient was diagnosed with severe oligospermia, and ICSI was deemed as the only feasible option for conception because the condition is relatively rare and has a diverse phenotype.
16