17 Papers
160 Citations
Xu He is an academic researcher from Simon Fraser University. The author has contributed to research in topics: Lysosomal storage disease & Biology. The author has an hindex of 10, co-authored 15 publications.
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Papers
Proteases associated with programmed cell death of megagametophyte cells after germination of white spruce (Picea glauca) seeds.
Xu He,Allison R. Kermode +1 more
TL;DR: It is proposed that the Cys-EP-related protein and CLP activity are involved in PCD of white spruce megagametophyte cells.
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Insights into mucopolysaccharidosis I from the structure and action of α- L -iduronidase
Haiying Bie,Jiang Yin,Xu He,Allison R. Kermode,Ethan D. Goddard-Borger,Stephen G. Withers,Michael N.G. James +6 more
TL;DR: Crystallized IDUA structures and biochemical analysis of the disease-relevant Pro533Arg mutation have enabled us to correlate the effects of mutations in IDUA to clinical phenotypes.
Nuclease activities and DNA fragmentation during programmed cell death of megagametophyte cells of white spruce (Picea glauca) seeds
Xu He,Allison R. Kermode +1 more
TL;DR: TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling)-positive nuclei indicated that the first megagametophyte cells to die were those closest to the radicle at the micropylar end of the seed as well as those that comprised the most peripheral and innermost layers at the chalazal end of
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Production of α- L -iduronidase in maize for the potential treatment of a human lysosomal storage disease
Xu He,Thomas Haselhorst,Mark von Itzstein,Daniel Kolarich,Daniel Kolarich,Nicolle H. Packer,Tracey M. Gloster,Tracey M. Gloster,David J. Vocadlo,Lorne A. Clarke,Yi Qian,Allison R. Kermode +11 more
TL;DR: It is demonstrated that the α-L-iduronidase protein and mRNA are targeted to endoplasmic reticulum (ER)-derived protein bodies and to protein body-ER regions, respectively, using regulatory (5'- and 3'-UTR) and signal-peptide coding sequences from the γ-zein gene.
Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach.
Qiuxia Chen,Chuan-Chuan Liu,Wei Wang,Xiaoyun Meng,Xuemin Cheng,Xianyang Li,Longying Cai,Linfu Luo,Xu He,Hua Qu,Jing Luo,Hong Wei,Sen Gao,Guansai Liu,Jinqiao Wan,David I. Israel,Jin Li,Deng-Feng Dou +17 more
TL;DR: In this article , a parallel screening approach that utilizes DNA barcodes as reporters of ternary complex formation and cooperative binding is presented. But the method is limited to a small number of possible PROTAC molecules.
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