Xiumei Chen
5 Papers
Xiumei Chen is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has co-authored 3 publications.
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Papers
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design.
Yang Yu,Junhong Huang,Hu Ming He,Jing Han,Geyan Ye,Tingyang Xu,Xianqiang Sun,Xiumei Chen,Xiao-Min Ren,Chunlai Li,Huijuan Li,Wei-Kwang Huang,Yangyang Liu,Xinjuan Wang,Yongzhi Gao,Nianhe Cheng,Na Guo,Xibo Chen,Jianxia Feng,Yu-Ran Hua,Chong Liu,Guoyun Zhu,Zhi Xie,Lina Yao,Wenge Zhong,Xinde Chen,Wei Liu,Hailong Li +27 more
TL;DR: In this article , a highly potent and selective macrocyclic CDK2 inhibitor QR-6401 (23) accelerated by the application of generative models and structure-based drug design (SBDD) is reported.
19
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway
Yahong Fu,Qiaowei Jia,Mengmeng Ren,Hengjie Bie,Xin Zhang,Qian Zhang,Shu He,Chengcheng Li,Hanxiao Zhou,Yanjun Wang,Xiong Gan,Zhengxian Tao,Xiumei Chen,En-Zhi Jia +13 more
TL;DR: This study provides the first direct evidence that circZBTB46 functions as an important regulatory molecule for CAD progression by interacting with hnRNPA2B1 and regulating the PTEN/AKT/mTOR pathway.
5
Detailed profiling of m6A modified circRNAs and synergistic effects of circRNA and environmental risk factors for coronary artery disease
Yahong Fu,Shu He,Chengcheng Li,Xiongkang Gan,Yanjun Wang,Yaqing Zhou,Rongli Jiang,Qian Zhang,Yang Pan,Hanxiao Zhou,Xiumei Chen,En-Zhi Jia +11 more
TL;DR: In this article , m6A modified RNA immunoprecipitation sequencing (MeRIP-seq) was conducted to investigate m6-methyladenosine (m6A) modified circRNAs in human coronary artery smooth muscle cells (HCASMCs) and to identify potential biomarkers for CAD.
5
Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease
Shu He,Yahong Fu,Chengcheng Li,Xiongkang Gan,Yanjun Wang,Hanxiao Zhou,Rongli Jiang,Qian Zhang,Qiao-Wei Jia,Xiumei Chen,En-Zhi Jia +10 more
TL;DR: In this paper , the authors explored the interaction of circRNA with classical coronary risk factors in coronary atherosclerotic disease by using RNA sequencing results from coronary segments and peripheral blood mononuclear cells.
Single-cell RNA sequencing atlas of peripheral blood mononuclear cells from subjects with coronary artery disease.
Xiaolong Song,Yahong Fu,Chengcheng Li,Qiaowei Jia,Mengmeng Ren,Xin Zhang,Hengjie Bie,Hanxiao Zhou,Xiong Gan,Shu He,Yanjun Wang,Shuang Zhang,Renyou Pan,Weixin Sun,Haitang Zhou,Qimeng Ni,Jun Song,Qian Zhang,Xiumei Chen,En-Zhi Jia +19 more
- 01 Sep 2023
TL;DR: Data provide a line of evidence that the JUN signaling pathway may be a potential diagnostic and therapeutic molecule target for CAD.