Xinyan Lu
Northwestern University
6 Papers
2 Citations
Xinyan Lu is an academic researcher from Northwestern University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 6 publications.
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Papers
FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
Yue Sheng,Yue Sheng,Chunjie Yu,Chunjie Yu,Yin Liu,Yin Liu,Chao Hu,Rui Ma,Xinyan Lu,Peng Ji,Jianjun Chen,Benjamin Mizukawa,Yong Huang,Jonathan D. Licht,Zhijian Qian,Zhijian Qian +15 more
TL;DR: This study shows a critical role and mechanisms of Foxm1 in MA9-LSCs, and indicates that FOXM1 is a potential therapeutic target for selectively eliminating LSCs in MLL-rearranged AML.
The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma.
Suyang Hao,Xinyan Lu,Zimu Gong,Roland L. Bassett,Shimin Hu,Sergej Konoplev,Guilin Tang,Shaoying Li,Jie Xu,Mahsa Khanlari,Hans C. Lee,Elisabet E. Manasanch,Donna M. Weber,Robert Z. Orlowski,L. Jeffrey Medeiros,Pei Lin +15 more
TL;DR: The findings indicate that the inferior outcome of myeloma patients with CKS1B gain/amp is attributable to the high number of high-risk patients in this group, as well as the background karyotype and TP53 status.
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High-risk human papillomavirus-mediated adenocarcinoma of palatine tonsil.
TL;DR: The case of a human papillomavirus-mediated adenocarcinoma of palatine tonsil in a 51-year-old male highlights the need to consider HPV testing in non-squamous cell carcinomas of the oropharynx.
3
Comprehensive molecular genetic studies of Epstein-Barr virus-negative aggressive Natural killer-cell leukemia/lymphoma
Juehua Gao,Yanming Zhang,Nabeel R. Yaseen,Yuqiang Fang,Xinyan Lu,Madina Sukhanova,Qing Chen,Yi Hua Chen +7 more
TL;DR: The strong expression of PD-L1 suggests that immune checkpoint inhibitors may be further explored as a potential therapeutic option for this highly aggressive, chemotherapy-resistant NK-cell neoplasm.
1
Aggressive morphologic variants of mantle cell lymphoma characterized with high genomic instability showing frequent chromothripsis, CDKN2A/B loss, and TP53 mutations: A multi-institutional study.
Lukas Streich,Madina Sukhanova,Xinyan Lu,Yi Hua Chen,Girish Venkataraman,Stephanie Mathews,Shanxiang Zhang,Katalin Kelemen,Jeremy P. Segal,Juehua Gao,Leo I. Gordon,Qing Chen,Amir Behdad +12 more
TL;DR: High genomic instability associated with chromothripsis and a high frequency of CDKN2A/B and TP53 alterations in the aggressive variants of MCL are described and may provide potential targets for alternative treatment.