Xinxin Chi
Tsinghua University
7 Papers
Xinxin Chi is an academic researcher from Tsinghua University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 3 publications.
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Papers
STAT3 regulates CD8+ T cell differentiation and functions in cancer and acute infection.
Qinli Sun,Xiaohong Zhao,Ruifeng Li,Dingfeng Liu,Birui Pan,Bowen Xie,Xinxin Chi,Dong Li Cai,Peng Wei,Wei Xu,Kun Wei,Zixuan Zhao,Yujie Fu,Ling Ni,Chen Dong +14 more
TL;DR: The role of STAT3 signaling in the development and function of terminally differentiated effector CD8+ T cells in acute infection was investigated in this paper , where it was found that STAT3 transcriptionally promotes the expression of effector function-related genes, while it suppresses those expressed by the progenitor Tex subset.
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Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3
Kentaro Tanaka,Kentaro Tanaka,Kentaro Tanaka,Gustavo J. Martinez,Xiaowei Yan,Weiwen Long,Kenji Ichiyama,Kenji Ichiyama,Kenji Ichiyama,Xinxin Chi,Byung Seok Kim,Joseph M. Reynolds,Yeonseok Chung,Shinya Tanaka,Lan Liao,Yoichi Nakanishi,Akihiko Yoshimura,Pan Zheng,Xiaohu Wang,Qiang Tian,Jianming Xu,Bert W. O'Malley,Chen Dong +22 more
TL;DR: It is shown that steroid receptor coactivator-3 (SRC-3) critically regulates Th 17 cell differentiation and is critical for RORγt-dependent gene expression in Th17 cell-driven autoimmune diseases.
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BCL6 promotes a stem-like CD8+ T cell program in cancer via antagonizing BLIMP1
Qinli Sun,Dong Li Cai,Di Liu,Xiaohong Zhao,Ruifeng Li,Wei Xu,Bowen Xie,Mengting Gou,Kun Wei,Yuling Li,Xinxin Chi,Peng Wei,Jing Hao,Xinyi Guo,Birui Pan,Yujie Fu,Ling Ni,Chen Dong +17 more
TL;DR: The TGF-β–BCL6 and IL-2–BLIMP1 antagonistic pathways in regulation of antitumor CD8+ T cells are identified, which may benefit the development of long-lasting and effective cancer immunotherapy.
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Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections
TL;DR: In this paper , a review of the etiology and pathogenesis of common autoimmune disorders from the perspective of human genetics is presented, with an overview of the genetic basis of autoimmunity followed by three chapters detailing susceptibility genes involved in innate immunity, adaptive immunity and inflammatory cell death processes respectively.
T Follicular Helper Cells Regulate Humoral Response for Host Protection against Intestinal Citrobacter rodentium Infection.
TL;DR: The role of T follicular helper cells in regulating humoral response for the host protection against C. rodentium infection is examined using mice with Bcl6 deficiency in T cells.
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