Xinhui Wang
Roswell Park Cancer Institute
37 Papers
187 Citations
Xinhui Wang is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Antigen & Monoclonal antibody. The author has an hindex of 14, co-authored 37 publications. Previous affiliations of Xinhui Wang include Hauptman-Woodward Medical Research Institute & New York Medical College.
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Papers
Multiple defects of the antigen-processing machinery components in human neuroblastoma: immunotherapeutic implications
Lizzia Raffaghello,Ignazia Prigione,Paola Bocca,Fabio Morandi,Marta Camoriano,Claudio Gambini,Xinhui Wang,Soldano Ferrone,Vito Pistoia +8 more
TL;DR: Low expression of human leukocyte antigen (HLA) class I in human tumors may be related to defects of the antigen-processing machinery (APM) components, which explain reduced peptide loading on HLA class I molecules, their instability and failure to be expressed on the cell surface.
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Immune Selection of Hot-Spot β2-Microglobulin Gene Mutations, HLA-A2 Allospecificity Loss, and Antigen-Processing Machinery Component Down-Regulation in Melanoma Cells Derived from Recurrent Metastases following Immunotherapy
TL;DR: The presence of multiple HLA class I Ag defects within a tumor cell population may reflect the accumulation of multiple escape mechanisms developed by melanoma cells to avoid distinct sequential T cell-mediated selective events.
A method to generate antigen-specific mAb capable of staining formalin-fixed, paraffin-embedded tissue sections
Xinhui Wang,Michael Campoli,Hyun Suk Cho,Takeshi Ogino,Nobuyuki Bandoh,Jijia Shen,Soo Young Hur,Toshiro Kageshita,Soldano Ferrone +8 more
TL;DR: The use of the methodology developed is likely to be applicable to other antigenic systems to develop mAb capable of detecting protein components of interest in formalin-fixed, paraffin-embedded tissue sections.
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Association of Antigen-Processing Machinery and HLA Antigen Phenotype of Melanoma Cells with Survival in American Joint Committee on Cancer Stage III and IV Melanoma Patients
Andrea Anichini,Roberta Mortarini,Daisuke Nonaka,Alessandra Molla,Claudia Vegetti,Elisabetta Montaldi,Xinhui Wang,Soldano Ferrone +7 more
TL;DR: It is suggested that quantitative variations in APM component and HLA expression in melanoma lesions from AJCC stage III and IV patients may have an effect on the clinical course of the disease.
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Targeting melanoma cells with human high molecular weight-melanoma associated antigen-specific antibodies elicited by a peptide mimotope: functional effects.
TL;DR: It is suggested that both immunological and nonimmunological mechanisms underlie the beneficial clinical effects associated with the induction of HMW-MAA-specific Abs in melanoma patients immunized with a HMW -MAA mimic.