Xinge Wang
Fourth Military Medical University
10 Papers
14 Citations
Xinge Wang is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease
Arun K. Jana,Xinge Wang,Joseph W. Leasure,Lissette Bonilla Magana,Li Wang,Young Mee Kim,Hemraj B. Dodiya,Peter T. Toth,Sangram S. Sisodia,Jalees Rehman +9 more
TL;DR: In this article , the authors performed an unbiased bulk RNA-sequencing analysis of brain endothelial cells (BECs) in female APP/PS1 transgenic mice and found that BECs showed higher levels of the Type I interferon-stimulated gene IFIT2.
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis
Sreeparna Chakraborty,Abhalaxmi Singh,Li Wang,Xinge Wang,Mark A. Sanborn,Zijing Ye,Mark Maienschein-Cline,Amitabha Mukhopadhyay,Balaji B. Ganesh,Asrar B. Malik,Jalees Rehman +10 more
TL;DR: Trained alveolar macrophages exhibit enhanced injury resolution via KLF4-MERTK-mediated efferocytosis, promoting a proresolving phenotype and restricting inflammatory lung injury in mice exposed to lethal pathogens.
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The mechanically activated p38/MMP-2 signaling pathway promotes bone marrow mesenchymal stem cell migration in rats.
Yang Zihui,Baolei Wu,Sen Jia,Yinghua Zhao,Rui Hou,Xiao-Chang Liu,Xinge Wang,Litong Chen,Xinjie Yang,Delin Lei,Lei Wang +10 more
TL;DR: This study is the first report demonstrating that the p38/MMP-2 axis governs BMMSC migration under static mechanical strain and can promote the migration ability of BMMSCs via p38-p-p38 signaling.
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Temporal transcriptomic analysis using TrendCatcher identifies early and persistent neutrophil activation in severe COVID-19
TL;DR: An open-source R package is developed, which applies the smoothing spline ANOVA model and break point searching strategy, to identify and visualize distinct dynamic transcriptional gene signatures and biological processes from longitudinal data sets, which uncovered the early and persistent activation of neutrophils and coagulation pathways in circulating cells in patients who progressed to severe COVID-19.
Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia
Young Mee Kim,Mark A. Sanborn,Xinge Wang,Georgina Mancinelli,Sreeparna Chakraborty,Shaluah Vijeth,Priyanka Gajwani,Paul J. Grippo,Steve Seung-Young Lee,Tibor Valyi-Nagy,Peter T. Toth,Klara Valyi-Nagy,Jalees Rehman +12 more
TL;DR: In this article , the role of the muscle vasculature in cancer cachexia was investigated using transgenic pancreatic ductal adenocarcinoma (PDAC) mice and a 3D-tissue imaging approach.
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