Xing Xu
Nantong University
10 Papers
22 Citations
Xing Xu is an academic researcher from Nantong University. The author has contributed to research in topics: Tail suspension test & Neuroinflammation. The author has an hindex of 6, co-authored 10 publications.
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Papers
The ketone body metabolite β-hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation
Chao Huang,Peng Wang,Xing Xu,Yaru Zhang,Yu Gong,Wenfeng Hu,Minhui Gao,Yue Wu,Yong Ling,Xi Zhao,Yibin Qin,Rongrong Yang,Wei Zhang +12 more
TL;DR: It is reported that BHB as well as its producing stimuli fasting and KD induced obvious ramifications of murine microglia in basal and inflammatory conditions in a reversible manner, and these ramifications were accompanied with microglial profile toward M2 polarization and phagocytosis.
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Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition
Peng Wang,Yaru Zhang,Yu Gong,Rongrong Yang,Zhuo Chen,Wenfeng Hu,Yue Wu,Minhui Gao,Xing Xu,Yibin Qin,Chao Huang +10 more
TL;DR: Results showed that SB induced reversible elongations of microglial process in both normal and inflammatory conditions, and these elongations were accompanied with significant changes in markers reflecting the pro-inflammatory and anti-inflammatory status of microGlia.
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Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation.
Yu Gong,Lijuan Tong,Rongrong Yang,Wenfeng Hu,Xingguo Xu,Wang Wenjing,Peng Wang,Xu Lu,Minhui Gao,Yue Wu,Xing Xu,Yaru Zhang,Zhuo Chen,Chao Huang +13 more
TL;DR: Results reveal an etiological role of hippocampal microglia loss in ESI‐induced depression and demonstrate that the restoration of microglial homeostasis in the hippocampus may serve as a therapeutic strategy for depression induced by early‐life stress.
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Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress.
Zixuan Cai,Ting Ye,Xing Xu,Minhui Gao,Yaru Zhang,Dan Wang,Yiming Gu,Haojie Zhu,Lijuan Tong,Jiashu Lu,Zhuo Chen,Chao Huang +11 more
TL;DR: The results indicate that a single LPS injection displays rapid and sustained antidepressant effects in chronically stressed mice likely through stimulating hippocampal microglia.
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Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice.
Peili Hu,Dan Wang,Yaru Zhang,Zixuan Cai,Ting Ye,Lijuan Tong,Xing Xu,Jiashu Lu,Fengguo Liu,Xu Lu,Chao Huang +10 more
TL;DR: The results reveal a possible mechanism for AIE-induced depression and demonstrate that the restoration of hippocampal microglial homeostasis may be a therapeutic strategy for depression induced by alcohol intake and withdrawal.
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