Xing Meng
New York State Department of Health
13 Papers
181 Citations
Xing Meng is an academic researcher from New York State Department of Health. The author has contributed to research in topics: Ryanodine receptor & RYR1. The author has an hindex of 11, co-authored 13 publications.
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Papers
Monolithic microfluidic mixing–spraying devices for time-resolved cryo-electron microscopy
Zonghuan Lu,Tanvir R. Shaikh,David Barnard,Xing Meng,Hisham Mohamed,Aymen S. Yassin,Carmen A. Mannella,Rajendra K. Agrawal,Rajendra K. Agrawal,Toh-Ming Lu,Terence Wagenknecht,Terence Wagenknecht +11 more
TL;DR: A methodology in which reaction components are mixed and allowed to react, and are then sprayed onto an EM grid as it is being plunged into cryogen, found that microdroplets produced by air atomization spread to sufficiently thin films on a millisecond time scale.
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Three-dimensional localization of serine 2808, a phosphorylation site in cardiac ryanodine receptor
Xing Meng,Bailong Xiao,Shitian Cai,Xiaojun Huang,Xiaojun Huang,Fei Li,Fei Li,Jeff Bolstad,Ramon Trujillo,Judith A. Airey,S.R. Wayne Chen,Terence Wagenknecht,Terence Wagenknecht,Zheng Liu +13 more
TL;DR: Two independent approaches have employed two independent approaches to map this phosphorylation site in RyR2 by three-dimensional cryo-electron microscopy, indicating that Ser-2808 is unlikely to be directly involved in the binding of FKBP12.6 toRyR2, as had been proposed previously.
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CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy.
Xing Meng,Guoliang Wang,Cedric Viero,Qiong-ling Wang,Wei Mi,Xiao-Dong Su,Terence Wagenknecht,Alan J. Williams,Zheng Liu,Chang-Cheng Yin +9 more
TL;DR: Data suggest that CLIC2 can interact with skeletal ryanodine receptor (RyR1) and modulate its channel activity and propose that CL IC2 functions as an intrinsic stabilizer of the closed state of RyR channels.
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Localization of the Dantrolene-binding Sequence near the FK506-binding Protein-binding Site in the Three-dimensional Structure of the Ryanodine Receptor
Ruiwu Wang,Xiaowei Zhong,Xing Meng,Andrea Koop,Xixi Tian,Peter P. Jones,Bradley R. Fruen,Terence Wagenknecht,Terence Wagenknecht,Zheng Liu,S. R. Wayne Chen +10 more
TL;DR: An allosteric mechanism by which dantrolene stabilizes interdomain interactions between the NH2-terminal and central regions of ryanodine receptors is proposed.
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Initial bridges between two ribosomal subunits are formed within 9.4 milliseconds, as studied by time-resolved cryo-EM
Tanvir R. Shaikh,Aymen S. Yassin,Zonghuan Lu,David Barnard,Xing Meng,Toh-Ming Lu,Terence Wagenknecht,Rajendra K. Agrawal +7 more
TL;DR: This study shows for the first time to the authors' knowledge that eight of the 12 bridges in the bacterial 70S ribosome form within 9.4 ms, whereas the remaining four bridges take longer than 43 ms to form, suggesting that bridges are formed in a stepwise fashion.
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