5 Papers
19 Citations
Xing Li is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Hyperphosphorylation & Cognitive deficit. The author has an hindex of 3, co-authored 4 publications.
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Papers
Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.
Xing Li,Xiaoqin Run,Zhen Wei,Kuan Zeng,Zhihou Liang,Fang Huang,Dan Ke,Qun Wang,Jian-Zhi Wang,Rong Liu,Bin Zhang,Xiaochuan Wang +11 more
TL;DR: Intranasal insulin administration might be a promising therapy to prevent anesthesiainduced cognitive deficit in elderly individuals.
19
ω-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB/BDNF/TrkB pathway.
Mao-sheng Fang,Xing Li,Hong Qian,Kuan Zeng,Meng Ye,Yong-jie Zhou,Hui Li,Xiaochuan Wang,Yi Li +8 more
TL;DR: π-3PUFAs enhances the CREB/BDNF/TrkB pathway by activating ERK and AKT, thereby increasing the synaptic plasticity and decreasing neuron loss, and antagonizing MK-801-induced cognitive impairment in schizophrenic rats.
19
USP10 deubiquitinates Tau, mediating its aggregation
Zhen Wei,Kuan Zeng,Jichang Hu,Xing Li,Fang-Ke Huang,Bin Zhang,Jian-Zhi Wang,Rong Liu,Hong-Lian Li,Xiaochuan Wang +9 more
TL;DR: Zhang et al. as discussed by the authors found that USP10 is upregulated in postmortem human AD and APP/PS1 mice brains, but not in P301S mice brains.
Long-term Helicobacter pylori infection does not induce tauopathy and memory impairment in SD rats.
Huan Zhou,Ying Guo,Xing Li,Zheng-Yu Liuyang,Yang-Ping Shentu,Xiaopeng Jing,Jia-Wei Liang,Xin-Wen Zhou,Xiaochuan Wang,Jian-Zhi Wang,Ji Zeng,Rong Liu +11 more
TL;DR: It is concluded that SD rat with long-term H.pylori colonization in the stomach is not a suitable animal model for exploring the effects of H.Pylori infection on brain function in human beings; administration of bacterial filtrates may better reveal the systemic pathologic changes induced by bacterial infection in animals which show a negative host response to bacterial colonization.
4
High salt induced hypertension leads to cognitive defect
Cuiping Guo,Zhen Wei,Fang Huang,Min Qin,Xing Li,Yuman Wang,Qun Wang,Jian-Zhi Wang,Jian-Zhi Wang,Rong Liu,Bin Zhang,Hong-Lian Li,Xiaochuan Wang,Xiaochuan Wang +13 more
TL;DR: It is found that long-term high salt intake caused a marked increase of systolic blood pressure linked to a declined regional cerebral blood flow, which suggests a novel etiopathogenic mechanism of cognitive deficit induced by hypertension, which is initiated by high salt diet.