Xing-Jun Liu
Chinese Academy of Sciences
23 Papers
11 Citations
Xing-Jun Liu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 5 publications.
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Papers
A central neural circuit for itch sensation
Di Mu,Juan Deng,Kefei Liu,Zhen-Yu Wu,Yu-Feng Shi,Wei-Min Guo,Qun-Quan Mao,Xing-Jun Liu,Hui Li,Yan-Gang Sun +9 more
TL;DR: It is found that the spinoparabrachial pathway was activated during itch processing and that optogenetic suppression of this pathway impaired itch-induced scratching behaviors, revealing a central neural circuit that is critical for itch signal processing.
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Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein-mediated stimulation of T-type calcium channels
Yuan Zhang,Wenjuan Qin,Zhiyuan Qian,Xing-Jun Liu,Hua Wang,Shan Gong,Yan-Gang Sun,Terrance P. Snutch,Xinghong Jiang,Jin Tao +9 more
TL;DR: IGF-1 enhances T-type channel currents through the activation of IGF-1R that is coupled to a G protein–dependent PKCα pathway, thereby increasing the excitability of DRG neurons and the sensitivity to pain.
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OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation
Xing-Jun Liu,Hong-Bo Deng,Jinhua Tang,Zixuan Wang,Chunchun Zhu,Xiao-Jing Cai,Fangjing Rong,Xiaoyun Chen,Xueyi Sun,Shuke Jia,Gang Ouyang,Wenhua Li,Wuhan Xiao +12 more
TL;DR: In this article , the authors found that OTUB1 augments hypoxia signaling independent of PHDs/VHL and FIH, and showed that it positively regulates HIF-1α transcriptional activity.
Expression patterns of T-type Cav3.2 channel and insulin-like growth factor-1 receptor in dorsal root ganglion neurons of mice after sciatic nerve axotomy.
TL;DR: The findings argue for an upregulation of Cav3.2 and IGF-1R expression in lumbar DRGs post-sciatic nerve axotomy and provided an insight for understanding the functions of peripheral afferent Cav 3.2 channel and insulin-like growth factor-1 (IGF-1) signaling in chronic neuropathic pain.
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Zebrafish sirt5 Negatively Regulates Antiviral Innate Immunity by Attenuating Phosphorylation and Ubiquitination of mavs
Xiaoyun Chen,Sijia Fan,Chunchun Zhu,Qian Liao,Jinhua Tang,Guangqing Yu,Xiao-Jing Cai,Gang Ouyang,Wuhan Xiao,Xing-Jun Liu +9 more
TL;DR: It is demonstrated that zebrafish sirt5, one of the sirtuin family proteins, negatively regulates mavs-mediated antiviral innate immunity.
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