Xin Zhang
Newcastle University
6 Papers
Xin Zhang is an academic researcher from Newcastle University. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Xin Zhang include Centre for Life & University of Newcastle.
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Papers
Derivation of Human Embryonic Stem Cells from Developing and Arrested Embryos
Xin Zhang,Petra Stojkovic,Stefan Przyborski,Michael J. Cooke,Lyle Armstrong,Majlinda Lako,Miodrag Stojkovic +6 more
TL;DR: Analysis of arrested embryos demonstrated that these embryos express pluripotency marker genes such OCT4, NANOG, and REX1, which demonstrate that arrested embryos are additional valuable resources to surplus and donated developing embryos and should be used to study early human development or derive pluripotent hESC.
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Putative Role of Hyaluronan and Its Related Genes, HAS2 and RHAMM, in Human Early Preimplantation Embryogenesis and Embryonic Stem Cell Characterization
Meenakshi Choudhary,Xin Zhang,Petra Stojkovic,Louise Hyslop,George Anyfantis,Mary Herbert,Alison Murdoch,Miodrag Stojkovic,Majlinda Lako +8 more
TL;DR: It is shown for the first time that HA synthase gene HAS2 and its binding receptor RHAMM are differentially expressed during all stages of preimplantation human embryos and hESC, highlighting an important role for RhamM in maintenance of hESc pluripotency, viability, and cell cycle control.
A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A
Xin Zhang,Irina Neganova,Stefan Przyborski,Chunbo Yang,Michael J. Cooke,Stuart P. Atkinson,George Anyfantis,Stefan Fenyk,W. Nicol Keith,S F Hoare,Owen Hughes,Tom Strachan,Miodrag Stojkovic,Philip W. Hinds,Lyle Armstrong,Majlinda Lako +15 more
TL;DR: It is shown that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components through C-terminal region binds to the regulatory regions of CDK6 and CDC25A genes under normal physiological conditions.
A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation.
Chunbo Yang,Stefan Przyborski,Stefan Przyborski,Michael J. Cooke,Michael J. Cooke,Xin Zhang,Rebecca Stewart,George Anyfantis,Stuart P. Atkinson,Gabriele Saretzki,Lyle Armstrong,Majlinda Lako +11 more
TL;DR: Modulated the expression of TERT indicated for the first time an important role for TERT in the maintenance of human ESC pluripotency, cell cycle regulation, and in vitro differentiation capacity.
Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells.
TL;DR: In this paper, the key regulators of the G1 to S transition in human embryonic stem cells (hESCs) were studied and compared to human embryonic carcinoma (EC) cells.