Xin-Xin Cui
Zhengzhou University
6 Papers
2 Citations
Xin-Xin Cui is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Neddylation & Hippo signaling pathway. The author has an hindex of 3, co-authored 6 publications.
Chat about Author
Papers
Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors.
TL;DR: Trimethoxyphenyl-1,2,3-triazole containing the coumarin fragement 19c displayed better antiproliferative activity results with IC50 values from 0.13 μM to 1.74 μM than anticancer drug colchicine.
59
Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway.
Jian Song,Qiu-Lei Gao,Bo-Wen Wu,Ting Zhu,Xin-Xin Cui,Cheng-Jun Jin,Shu-Yu Wang,Sheng-Hui Wang,Dong-Jun Fu,Hong-Min Liu,Sai-Yang Zhang,Yan-Bing Zhang,Yongchun Li +12 more
TL;DR: Compound F10 was the first to be reported as a new anticancer agent in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway and binding tightly into the colchicine binding site of β-tubulin.
50
Discovery of 1,2,4-triazine-based derivatives as novel neddylation inhibitors and anticancer activity studies against gastric cancer MGC-803 cells.
Jian Song,Xin-Xin Cui,Bo-Wen Wu,Dong Li,Sheng-Hui Wang,Lei Shi,Ting Zhu,Yan-Bing Zhang,Sai-Yang Zhang +8 more
TL;DR: The discovery of a hit scaffold from the in-house library and further structure-based optimizations suggest that 1,2,4-triazine scaffold might provide a novel scaffold for the further development of neddylation inhibitors and compound V11 might be a potential neddyation inhibitor with anticancer activity.
21
Discovery of novel indole derivatives that inhibit NEDDylation and MAPK pathways against gastric cancer MGC803 cells.
Dong-Jun Fu,Xin-Xin Cui,Ting Zhu,Yan-Bing Zhang,Yang-Yang Hu,Li-Rong Zhang,Sheng-Hui Wang,Sai-Yang Zhang +7 more
TL;DR: A series of novel indole derivatives were synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (MGC803, EC-109 and PC-3) as discussed by the authors.
21