Xin Tan
Paris Descartes University
7 Papers
6 Citations
Xin Tan is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Staphylococcus aureus & Transketolase. The author has an hindex of 4, co-authored 7 publications. Previous affiliations of Xin Tan include French Institute of Health and Medical Research & University of Paris.
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Papers
Intracellular Survival of Staphylococcus aureus in Endothelial Cells: A Matter of Growth or Persistence.
Guillaume Rollin,Guillaume Rollin,Xin Tan,Xin Tan,Fabiola Tros,Fabiola Tros,Marion Dupuis,Marion Dupuis,Xavier Nassif,Xavier Nassif,Xavier Nassif,Alain Charbit,Alain Charbit,Mathieu Coureuil,Mathieu Coureuil +14 more
TL;DR: It is suggested that internalization of S. aureus in endothelial cells triggers its persistence and support the notion that endothelium cells might constitute an intracellular persistence niche responsible for reported relapse of infection after antibiotic therapy.
Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence.
Xin Tan,Mathieu Coureuil,Elodie Ramond,Daniel Euphrasie,Marion Dupuis,Fabiola Tros,Julie Meyer,Ivan Nemazanyy,Cerina Chhuon,Ida Chiara Guerrera,Agnès Ferroni,Isabelle Sermet-Gaudelus,Xavier Nassif,Alain Charbit,Anne Jamet +14 more
TL;DR: The results strongly suggest that the intracellular environment might constitute an important niche of persistence and relapse necessitating adapted antibiotic treatments, and identify the underlying genetic modifications inducing altered protein expression profiles and notable metabolic changes that could constitute therapeutic targets.
Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection.
Xin Tan,Xin Tan,Elodie Ramond,Elodie Ramond,Anne Jamet,Anne Jamet,Jean-Philippe Barnier,Jean-Philippe Barnier,Baptiste Decaux-Tramoni,Baptiste Decaux-Tramoni,Marion Dupuis,Marion Dupuis,Daniel Euphrasie,Daniel Euphrasie,Fabiola Tros,Fabiola Tros,Ivan Nemazanyy,Ivan Nemazanyy,Ivan Nemazanyy,Jason Ziveri,Jason Ziveri,Xavier Nassif,Xavier Nassif,Alain Charbit,Alain Charbit,Mathieu Coureuil,Mathieu Coureuil +26 more
TL;DR: It is shown that inactivation of the unique gene encoding transketolase activity in S. aureus USA300 (∆tkt) led to drastic metabolomic changes, which suggests that TKT -or a functional PPP- strongly influences the ability of S.aureus to proliferate within host cells by modulating key transcriptional regulators.
Multitasking Actors of Staphylococcus aureus Metabolism and Virulence.
Xin Tan,Xin Tan,Mathieu Coureuil,Mathieu Coureuil,Alain Charbit,Alain Charbit,Anne Jamet,Anne Jamet,Anne Jamet +8 more
TL;DR: This work highlights recent major advances linking lipid and nucleic acid pathways to virulence regulation in Staphylococcus aureus.
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Persistent Staphylococcus aureus infections in children with chronic lung disease: a multi-omics analysis of bacterial adaptation to define novel therapeutic approaches
Xin Tan,Mathieu Coureuil,Elodie Ramond,Daniel Euphrasie,Marion Dupuis,Fabiola Tros,Julie Meyer,Ivan Nemanzny,Cerina Chhuon,Ida Chiara Guerrera,Agnès Ferroni,Isabelle Sermet-Gaudelus,Xavier Nassif,Alain Charbit,Anne Jamet +14 more
TL;DR: It is demonstrated that chronic infection with S. aureus is related to the accumulation of genetic modifications inducing altered protein expression profiles and notable metabolic changes, and that the intracellular environment might constitute an important niche of persistence and relapse necessitating adapted antibiotic treatments.