8 Papers
18 Citations
Xin Sun is an academic researcher from Hudson Institute of Medical Research. The author has contributed to research in topics: DNA methylation & Mitochondrial DNA. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Xin Sun include Monash University, Clayton campus & Monash University.
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Papers
The role of the mtDNA set point in differentiation, development and tumorigenesis.
TL;DR: The present review combines multi-disciplinary data from mitochondria, development, epigenetics and tumorigenesis, which could provide novel insights for further research, especially for developmental disorders and cancers.
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Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours.
TL;DR: It is determined that restoration of mtDNA copy number caused significant changes to both the nuclear methylome and its transcriptome for each tumour type, and the affected genes were specifically associated with gene networks and pathways involving behaviour, nervous system development, cell differentiation and regulation of transcription and cellular processes.
The transgenerational effects of oocyte mitochondrial supplementation.
Justin C. St. John,Justin C. St. John,Yogeshwar Makanji,Yogeshwar Makanji,Jacqueline Johnson,Jacqueline Johnson,Te-Sha Tsai,Te-Sha Tsai,Simone Lagondar,Fleur Rodda,Xin Sun,Xin Sun,Mulyoto Pangestu,Penny Chen,Peter Temple-Smith +14 more
TL;DR: Mitochondrial supplementation appears to perturb the regulation of the chromosomal genome resulting in transgenerational phenotypic gains and losses and the need for caution when using autologous mitochondrial supplementation to treat female factor infertility is highlighted.
The mitochondrial genome: how it drives fertility
TL;DR: This review analyse how the mitochondrial genome influences the developing embryo and cellular differentiation, as well as fetal and offspring health and wellbeing, and how modulating the mitochondrial content in the oocyte influences embryo viability and the potential to generate enhanced offspring for livestock production purposes.
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Global DNA methylation synergistically regulates the nuclear and mitochondrial genomes in glioblastoma cells.
TL;DR: Key methylated regions modulated by the DNA demethylation agents that also induced synchronous changes to mtDNA copy number and nuclear gene expression are identified and highlight the control exerted by DNA methylation on the expression of key genes, the regulation of mtDNAcopy number and establishment of the mtDNA set point, which collectively contribute to tumorigenesis.