7 Papers
Xin Liu is an academic researcher from Huazhong Agricultural University. The author has contributed to research in topics: Somatic cell nuclear transfer & Blastocyst. The author has an hindex of 3, co-authored 7 publications.
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Papers
Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA.
Ke Zhang,Dan-Ya Wu,Hui Zheng,Yao Wang,Qiao-Ran Sun,Xin Liu,Li-Yan Wang,Wen-Jing Xiong,Qiujun Wang,James D.P. Rhodes,Kai Xu,Lijia Li,Zili Lin,Guang Yu,Weikun Xia,Bo Huang,Zhenhai Du,Yao Yao,Kim Nasmyth,Robert J. Klose,Yi-Liang Miao,Wei Xie +21 more
TL;DR: Multi-step reprogramming of 3D chromatin architecture during SCNT is revealed and dual roles of cohesin in TAD formation and minor zygotic genome activation genes are support and minor ZGA repression is found.
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Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy.
Jilong Zhou,Zhouyiyuan Xue,Hai-Nan He,Xin Liu,Shu-Yuan Yin,Dan-Ya Wu,Xia Zhang,Heide Schatten,Yi-Liang Miao +8 more
- 13 Dec 2019
TL;DR: It is found that resveratrol could delay postovulatory aging and improve developmental competence of oocytes through activating selective mitophagy in the mouse and an involvement of FoxO3a in regulating mitophagic in aging oocytes following resver atrol treatment is observed.
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Maternal Cytokines CXCL12, VEGFA, and WNT5A Promote Porcine Oocyte Maturation via MAPK Activation and Canonical WNT Inhibition
Xin Liu,Hao Yuchen,Zhekun Li,Jilong Zhou,Hongmei Zhu,Guowei Bu,Zhiting Liu,Xudong Hou,Xia Zhang,Yi-Liang Miao +9 more
TL;DR: It is determined that maturation improvement by CVW is achieved through activating the MAPK pathway in advance and inhibiting the canonical WNT pathway at the end of the IVM period, which provides a new combination of three cytokines to promote the porcine IVM process, which also holds potential to be used in human assisted reproduction technologies as well as in other species.
TDG is a pig-specific epigenetic regulator with insensitivity to H3K9 and H3K27 demethylation in nuclear transfer embryos.
Xin Liu,Lu Chen,Tao Wang,Jilong Zhou,Zhekun Li,Guowei Bu,Jing-Jing Zhang,Shu-Yuan Yin,Dan-Ya Wu,Cheng-Li Dou,Tian Xu,Hai-Nan He,Wei Zhu,Longtao Yu,Zhiting Liu,Xia Zhang,Zhen-Xia Chen,Yi-Liang Miao +17 more
TL;DR: In this paper, a combination of H3K9me3 demethylase KDM4A and GSK126 was used to remove epigenetic barriers and restore the global transcriptome in pig SCNT embryos.
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CHIR99021 and rpIL6 promote porcine parthenogenetic embryo development and blastocyst quality
TL;DR: It is demonstrated that glycogen synthase kinase-3 (GSK3) inhibitor, CHIR99021 and recombinant porcine interleukin-6 (rpIL6) significantly promote porcines parthenogenetic blastocyst formation and subsequently porcINE pluripotent stem cells (pPSCs) derivation efficiency.
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