Xin Li
Cornell University
17 Papers
66 Citations
Xin Li is an academic researcher from Cornell University. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 9, co-authored 14 publications. Previous affiliations of Xin Li include University of Georgia.
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Papers
CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi.
Irina Leonardi,Xin Li,Alexa Semon,Dalin Li,Itai Doron,Gregory G. Putzel,Agnieszka S. Bar,Daniel Prieto,Maria Rescigno,Dermot P.B. McGovern,Jesús Pla,Iliyan D. Iliev +11 more
TL;DR: The results unravel a role of CX3CR1+ MNPs in mediating interactions between intestinal mycobiota and host immunity at steady state and during inflammatory disease.
Gut Mycobiota in Immunity and Inflammatory Disease
TL;DR: G gaps in knowledge are discussed and the importance of considering bacteria-fungal interactions as they aim to define the roles of mycobiota in immune homeostasis and immune-associated pathologies are argued.
180
Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies.
Itai Doron,Irina Leonardi,Xin Li,William D. Fiers,Alexa Semon,Meghan Bialt-DeCelie,Mélanie Migaud,Mélanie Migaud,Iris H. Gao,Woan-Yu Lin,Takato Kusakabe,Anne Puel,Anne Puel,Anne Puel,Iliyan D. Iliev +14 more
TL;DR: In this paper, a multi-kingdom antibody profiling (multiKAP) approach was used to explore the human antibody repertoires against gut commensal fungi (mycobiota).
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Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease.
Itai Doron,Marissa Mesko,Xin Li,Takato Kusakabe,Irina Leonardi,Dustin G. Shaw,William D. Fiers,Woan-Yu Lin,Meghan Bialt-DeCelie,Elvira Román,Randy S. Longman,Jesús Pla,Patrick C Wilson,Patrick C Wilson,Iliyan D. Iliev +14 more
TL;DR: In this paper, the human gut mycobiota bound by secretory immunoglobulin A (sIgA) revealed a preference for hyphae, a fungal morphotype associated with virulence.
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Response to Fungal Dysbiosis by Gut-Resident CX3CR1+ Mononuclear Phagocytes Aggravates Allergic Airway Disease.
Xin Li,Irina Leonardi,Alexa Semon,Itai Doron,Iris H. Gao,Gregory G. Putzel,Young Jun Kim,Hiroki Kabata,David Artis,William D. Fiers,Amanda E. Ramer-Tait,Iliyan D. Iliev +11 more
TL;DR: It is shown that fluconazole-induced gut fungal dysbiosis has persistent effects on allergic airway disease in a house dust mite challenge model and disruption of intestinal fungal communities can have persistence effects on peripheral immunity and aggravate disease severity through fungal sensing by gut-resident CX3CR1+ MNPs.
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