Xin Jia
Sun Yat-sen University
5 Papers
Xin Jia is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Polyadenylation & Helicase. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Xin Jia include Beijing University of Chinese Medicine.
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Papers
Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
Yao Wang,Shaochun Yuan,Xin Jia,Yong Ge,Tao Ling,Meng Nie,Xihong Lan,Shangwu Chen,Anlong Xu,Anlong Xu +9 more
TL;DR: It is demonstrated that zinc finger NFX1-type containing 1 (ZNFX1), a helicase SF1, is an interferon (IFN)-stimulated, mitochondrial-localised dsRNA sensor that specifically restricts the replication of RNA viruses.
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The role of alternative polyadenylation in the antiviral innate immune response.
Xin Jia,Shaochun Yuan,Yao Wang,Yonggui Fu,Yong Ge,Yutong Ge,Xihong Lan,Yuchao Feng,Feifei Qiu,Peiyi Li,Shangwu Chen,Anlong Xu,Anlong Xu +12 more
TL;DR: This study reports the annotation of genes with APA in antiviral immunity and highlights the roles of 3′ processing factors on 3′ UTR variation upon viral infection.
Degradation of WTAP blocks antiviral responses by reducing the m6A levels of IRF3 and IFNAR1 mRNA
Yong Ge,Tao Ling,Yao Wang,Yao Wang,Xin Jia,Xin Jia,Xiongmei Xie,Rong Chen,Shangwu Chen,Shaochun Yuan,Anlong Xu,Anlong Xu +11 more
TL;DR: In this article, the role of m6 A modification in type I interferon (IFN-I) signaling was investigated and it was shown that m6-methyladenosine (m6 A) is a chemical modification present in multiple RNA species and is most abundant in mRNAs.
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DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS.
Jie Ruan,Yange Cao,Tao Ling,Peiyi Li,Shengpeng Wu,Dezhi Peng,Yao Wang,Xin Jia,Shangwu Chen,Anlong Xu,Anlong Xu,Shaochun Yuan +11 more
TL;DR: This comparative immunological study defined DDX23 as an emerging nuclear pattern recognition receptor (PRR) for the innate sensing of an RNA virus, but also extended the essential role of the DExD/H helicase family in viral RNA sensing from mammals to basal chordates.
Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation.
Feifei Qiu,Yonggui Fu,Chan Lu,Yuchao Feng,Qiong Wang,Zhanfeng Huo,Xin Jia,Chengyong Chen,Shangwu Chen,Anlong Xu,Anlong Xu +10 more
TL;DR: This work proposes that the APA switching of STAT5B induced by TCR activation is mediated by small nuclear ribonucleoprotein polypeptide A (SNRPA), and found that p65 activation triggered by T CR signaling could promote SNRPA transcription and 3′ UTR shortening ofSTAT5B.