Xin Huang
Chinese Academy of Sciences
7 Papers
151 Citations
Xin Huang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Glycosylation & Griffithsin. The author has an hindex of 7, co-authored 7 publications.
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Papers
Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction.
Xin Huang,Wei Jin,Kai Hu,Sukun Luo,Tao Du,George E. Griffin,Robin J. Shattock,Qinxue Hu,Qinxue Hu +8 more
TL;DR: This study demonstrates for the first time that removal of individual glycan N156, N262 or N410 proximal to CD4-binding region impairs viral infectivity and results in enhanced capability to induce neutralizing activity.
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CCL19 and CCL28 Augment Mucosal and Systemic Immune Responses to HIV-1 gp140 by Mobilizing Responsive Immunocytes into Secondary Lymph Nodes and Mucosal Tissue
Kai Hu,Sukun Luo,Lina Tong,Xin Huang,Wei Jin,Wenjie Huang,Tao Du,Yan Yan,Siyi He,George E. Griffin,Robin J. Shattock,Qinxue Hu,Qinxue Hu +12 more
TL;DR: PCCL19 and pCCL28 can enhance HIV-1 envelope–specific systemic and mucosal Ab responses, as well as T cell responses, and such enhancements appear to be associated with mobilization of responsive immunocytes into secondary lymphoid organs and mucosa tissues through interactions with corresponding receptors.
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Contribution of N-linked glycans on HSV-2 gB to cell–cell fusion and viral entry
Sukun Luo,Kai Hu,Siyi He,Ping Wang,Mudan Zhang,Xin Huang,Tao Du,Chunfu Zheng,Yalan Liu,Qinxue Hu,Qinxue Hu +10 more
TL;DR: Mutation at N390, N483 or N668 decreased cell-cell fusion and viral entry, while mutation at N133 mainly affected protein expression and the production of infectious virus particles by blocking the transport of gB from the endoplasmic reticulum to Golgi.
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Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin
TL;DR: It is demonstrated that a single deglycosylation at N295 or N448 in a range of primary and T-cell-line-adapted HIV-1 isolates resulted in marked resistance to griffithsin (GRFT) but maintained the sensitivity to cyanovirin, Galanthus nivalis agglutinin (GNA) and arange of neutralizing antibodies.
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C-C chemokine receptor type 5 (CCR5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule CCR5 inhibitors
TL;DR: Findings demonstrate that T/F R5 Envs are heterogeneous with respect to the mechanisms of CCR5 utilization, which may have implications for therapeutic and prophylactic use of C CR5-based antiretrovirals.
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