Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological and pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, and traumatic tissue injuries. By unraveling the intricate underpinnings of the molecular machinery, pivotal contributors, intricate signaling conduits, and regulatory networks governing ferroptosis, researchers aim to bridge the gap between the intricacies of this unique mode of cellular death and its multifaceted implications for health and disease. In light of the rapidly advancing landscape of ferroptosis research, we present a comprehensive review aiming at the extensive implications of ferroptosis in the origins and progress of human diseases. This review concludes with a careful analysis of potential treatment approaches carefully designed to either inhibit or promote ferroptosis. Additionally, we have succinctly summarized the potential therapeutic targets and compounds that hold promise in targeting ferroptosis within various diseases. This pivotal facet underscores the burgeoning possibilities for manipulating ferroptosis as a therapeutic strategy. In summary, this review enriched the insights of both investigators and practitioners, while fostering an elevated comprehension of ferroptosis and its latent translational utilities. By revealing the basic processes and investigating treatment possibilities, this review provides a crucial resource for scientists and medical practitioners, aiding in a deep understanding of ferroptosis and its effects in various disease situations. 

The mechanism of ferroptosis and its related diseases

Kinematics and improved surface roughness model in milling

Fairness issues have been frequently mentioned in the business world. In the context of today's global e-platform economy, this is more likely to breed fairness concerns due to the inherent power differential between e-platforms and third-party sellers (3P sellers). This article focuses on the impact of fairness concerns and power structures on the performance of supply chain members. In this article, we develop a game-theoretic model consisting of e-platform and 3P seller. The results of this article show that different power structures have different influences on the existence of fairness concerns. When the power structure tends to be balanced, the emergence of fairness concerns reduces the total efficiency of the supply chain system. When the e-platform is in a strong position, the emergence of fairness concerns has no effect on the supply chain system. It is also found that although the fairness concerns of the 3P seller cannot positively affect the supply chain as a whole, for the 3P seller itself, the emergence of fairness concerns can realize the transfer of profit distribution from the e-platform to the 3P seller by resetting the commission. In addition to the contribution of the theoretical part, some management insights are gained in this article. Supply chain members need to pay attention to the relationship management among supply chain members (e.g., fairness concern psychology). From the perspective of resource allocation, fairness and efficiency sometimes cannot coexist, and the stability of the supply chain and overall high efficiency sometimes cannot coexist. 

How Do Fairness Concern and Power Structure Affect Competition Between E-Platforms and Third-Party Sellers?

PurposeWith the vigorous development of the e-commerce delivery service industry, delivery service has become an important factor for e-tailers to obtain the market competitive advantage. However, how to choose the best delivery service strategy is a difficult problem for e-tailers in practice. The purpose of this paper is to investigate the effect of delivery service on e-tailers and online platforms.Design/methodology/approachBased on the Stackelberg game, the research study establishes and solves three models, namely dual self-supporting delivery service model, dual third-party delivery service model and differential delivery service model.FindingsThe results show that when the self-supporting and third-party delivery cost coefficients are all small, no matter which delivery service providers the competitor selects, the e-tailer selects delivery with a lower service fee. When the self-supporting and third-party delivery service fee are all low, no matter which delivery service providers the competitor selects, the e-tailer selects delivery with a smaller service cost. Both service fee and service cost determine the choice of e-tailers' delivery strategy. When the commission rate is moderate, both e-tailers are willing to choose the self-supporting delivery strategy, but the platform only prefers to provide self-supporting delivery to them with a lower delivery service sensitivity coefficient.Originality/valueThis paper analyzes the optimal delivery service strategies for e-tailers to compete with competitors, and explores the impacts of parameters for e-tailers and online platforms in their decision-making. The findings provide valuable implications for relevant practices.

Self-supporting or third-party? The optimal delivery strategy selection decision for e-tailers under competition

Recommendation agents: an analysis of consumers’ risk perceptions toward artificial intelligence

The impact of recommender systems and pricing strategies on brand competition and consumer search

Fabrication, Characteristics and Hydrothermal Stability of Methyl-Modified Ni-Co/Sio2 Membranes for H2/Co2 Separation

Uncertainty of Uncertainty and Accounting Conservatism

Institutional Investors’ Corporate Site Visits and Aggressive Financial Reporting

Analysis of Grinding Mechanics and Improved Grinding Force Model Based on Randomized Grain Morphological Characteristics

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