Rational design of AIE-based fluorescent probes for hypochlorite detection in real water samples and live cell imaging.

Emerging near infrared fluorophore: Dicyanoisophorone-based small-molecule fluorescent probes with large stokes shifts for bioimaging

Phenothiazine-coumarin-pyridine hybrid as an efficient fluorescent probe for ratiometric sensing hypochlorous acid

Green-emitting carbon quantum dots as a dual-mode fluorescent and colorimetric sensor for hypochlorite

A mitochondria-targeted fluorescent probe with large Stokes shift for rapid detection of hypochlorite and its application in living cells

Hypochlorous acid (HOCl)/hypochlorite (OCl−), an important reactive oxygen species, plays a number of important roles in various physiological processes. However, abnormal levels of OCl− can cause many serious diseases, such as atherosclerosis, rheumatoid arthritis, cardiovascular disease, and cancer. The development of efficient methods to monitor OCl− in biological systems is therefore of particular importance. Thus, we herein report a novel isophorone-based fluorescent probe, i.e., DCOH-FR-OCl, for OCl− detection. This probe was found to exhibit colorimetric and far-red ratiometric fluorescence response signals, excellent selectivity and sensitivity for OCl− (detection limit, 88.06 nM), a remarkably large Stokes shift (158 nm), an ultrafast response (completed within 3 s), perfect photostability, and good water solubility (100% in aqueous media). DCOH-FR-OCl, as we know, is the first probe that can detect OCl− by using two different response signals at an ultrafast speed with a large Stokes shift in fully aqueous media. Furthermore, DCOH-FR-OCl can be successfully employed in the real-time imaging of endogenous and exogenous OCl− in living cells.

A novel colorimetric and far-red emission ratiometric fluorescent probe for the highly selective and ultrafast detection of hypochlorite in water and its application in bioimaging.

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A novel colorimetric and far-red emission ratiometric fluorescent probe for the highly selective and ultrafast detection of hypochlorite in water and its application in bioimaging.