Xin Chen
Nanjing Medical University
8 Papers
1 Citations
Xin Chen is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination.
Zebing Rao,Xin Chen,Junxian Wu,Mengjun Xiao,Jing Zhang,Binghao Wang,Lei Fang,Hongjie Zhang,Xiaoming Wang,Shuo Yang,Yunzi Chen +10 more
TL;DR: It is demonstrated that VDR signaling constrains NLRP3 inflammasome activation and might be a potential treatment target for NLRP2 inflammaome-related diseases.
SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication
Pan Pan,Weiwei Ge,Zhiwei Lei,Wei Luo,Zhanwen Guan,Zhenyang Yu,Miaomiao Shen,Dingwen Hu,Qi Xiang,Wenbiao Wang,Pin Wan,Mingfu Tian,Yang Yu,Zhen Luo,Xulin Chen,Heng Xiao,Qiwei Zhang,Xu-Jing Liang,Xin Chen,Yongkui Li,Jianguo Wu +20 more
TL;DR: Wang et al. as mentioned in this paper found SARS-CoV-2 virus-like particles (trVLP) suppressed cell apoptosis, but the trVLP lacking N protein didn't.
A vaccine delivery system promotes strong immune responses against SARS‐CoV‐2 variants
Zhiwei Lei,Leqing Zhu,Pan Pan,Zhihui Ruan,Yu Gu,Xichun Xia,Shengli Wang,Weiwei Ge,Y. Yao,Fazeng Luo,Heng Xiao,Jun Guo,Qiang Ding,Zhinan Yin,Yongkui Li,Zhen Luo,Qiwei Zhang,Xin Chen,Jianguo Wu +18 more
TL;DR: Li et al. as mentioned in this paper developed an extended-release vaccine delivery system (GP•diABZI•RBD), consisting the original SARS•CoV•2 WA1 strain receptor-binding domain (RBD) as the antigen and diABZI stimulator of interferon genes (STING) agonist in conjunction with yeast β-glucan particles (GP‐diABzi) as a platform.
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Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice.
Yifei Zhou,Hao Chai,Yun-xin Hu,Renjie Liu,Hongwei Jiang,Ruihua Fan,Wen Chen,Fuhua Huang,Xin Chen +8 more
TL;DR: In this paper , the authors used an adeno-associated virus to construct gene-overexpressing mice to induce abdominal aortic aneurysm development through AngII infusion.
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Glycosylated, Lipid-Binding, CDR-Like Domains of SARS-CoV-2 ORF8 Indicate Unique Sites of Immune Regulation
Fang Wu,Xin Chen,Yan-hong Ma,Yuzhe Wu,Rui Li,Yuan-Peng Huang,Rong Zhang,Yaoqi Zhou,Jian Zhan,Shuwen Liu,Wei Xu +10 more
TL;DR: In this paper , the authors used X-ray crystallography to determine the structure of SARS-CoV-2 ORF8 protein, a unique accessory protein expressed in mammalian cells, at a resolution of 2.3
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