Surface-Enhanced Raman scattering (SERS) filter paper substrates decorated with silver nanoparticles for the detection of molecular vibrations of Acyclovir drug.

Multi-functional silver nanoprism-titanium dioxide hybrid nanoarrays for trace-level SERS sensing and photocatalytic removal of hazardous organic pollutants

This proof-of-concept research reports a label and bio-active free electrochemical testosterone (hormone essential regulating body function) sensing at low and in physiological range using molecularly imprinted polymers (MIPs)-based electrochemical sensing platform. State-of-the-art testosterone testing is clinical-based involving expertise, sophisticated laboratory set-up, and time-consuming testing and analysis. These consequences are limiting testosterone testing regularly suitable for an average person and a wide population. To manage these challenges, o-phenylenediamine (oPD) electropolymerized to poly(o-phenylenediamine) i.e., PoPD using cyclic voltammetry within minutes for fabricating MIP onto miniaturized screen-printed-electrode (SPE) for electrical testosterone sensing application. PoPD-MIPs/SPE sensor was responsive to varied concentrations of testosterone and exhibited a detection limit (LoD) of 1 ng/dL and a wide detection ranging from 1 to 25 ng/dL. The observed LoD correlates with the salivary testosterone of a healthy male. Therefore, PoPD-MIPs/SPE sensor, interfaced with a miniaturized potentiostat (M−P) and smartphone, has the potential of point-of-care (POC) testosterone sensing. 

Label and bio-active free electrochemical detection of testosterone hormone using MIP-based sensing platform

In this study, a target induced DNAzyme amplifaction strategy was developed combining with peanut-shaped FexOy@macro-/mesoporous carbon (MMC)@Au and covalent organic frameworks (COF)@Au to construct surface enhanced Raman spectrum (SERS) aptasensor for ultrasensitive detection of chloramphenicol (CAP). The polydopamine was firstly self-polymerized on the peanut-shaped Fe2O3 as a reductant to generate a uniform assembly of AuNPs, with multiple hotspots, to achieve high reproducibility. After carbonation process, the obtained magnetic peanut-shaped FexOy@MMC@Au could effectively avoid the Raman interference of the SERS substrate. When target CAP was dropped into the aptamer and DNAzyme double chains, CAP could specifically combining with aptamer, releasing DNAzyme chain to cut off hairpin DNA which was already assembled on the FexOy@MMC@Au. At this time, COF@Au@toluidine blue (TB)@S1 can be attract closed to the SERS substrate due to the complementation of S1 with residual hairpin DNA to produce strong Raman signal. Based on this principle, the SERS aptasensor for the detection of CAP possessed a very low limit of detection (LOD) of 7.35 fM was obtained. The results suggested the potential of this SERS aptasensor for sensitive and selective CAP diagnosis and be applied to the clinical and biochemical analysis. 

DNAzyme amplifaction strategy coupled with peanut-shaped FexOy@MMC@Au and COF@Au synergistic SERS enhancement for ultrasensitive analysis of chloramphenicol

Precise and specific miRNA detection plays a vital role in exploring development mechanisms of cancer disease, thereby it can significantly improve relevant prevention and treatment strategies. In this work, a surface-enhanced Raman spectroscopy (SERS)-based microfluidic chip has been devised with a microcone array SERS substrate (MCASS) for the miR-141 detection. This substrate excels in unique SERS activity and large surface area for DNA oligonucleotide modification. As the presence of miR-141, the DNAzyme walker induced cleavage reaction took place on the finely designed and prepared dual DNA conjugated SERS nanoprobes. The SERS nanoprobes can anchor on MCASS by the DNA hybridization that achieved an impressive detection limit in the femtomolar level. With this integrated SERS-based microfluidic chip, we provided a miRNA detection strategy using DNAzyme walker amplification technology. It is believed that this strategy could be a powerful tool for miRNA detection and related cancer screening test. 

A micro-nano interface integrated SERS-based microfluidic sensor for miRNA detection using DNAzyme walker amplification

A controllable SERS biosensor for ultrasensitive detection of miRNAs based on porous MOFs and subject-object recognition ability.

The capability to monitor doping in a rapid and sensitive manner is highly promising in the field of doping control.

Rapid and ultra-sensitive testosterone detection via aptamer-functional gold nanoparticles

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A controllable SERS biosensor for ultrasensitive detection of miRNAs based on porous MOFs and subject-object recognition ability.

Rapid and ultra-sensitive testosterone detection via aptamer-functional gold nanoparticles