Xijing Chen
China Pharmaceutical University
5 Papers
16 Citations
Xijing Chen is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Oxiracetam & Reductase. The author has an hindex of 5, co-authored 5 publications.
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Papers
Comparative pharmacokinetic studies of racemic oxiracetam and its pure enantiomers after oral administration in rats by a stereoselective HPLC method.
Qiuyang Zhang,Wei Yang,Yue Yang,Han Xing,Qing Zhang,Junxiu Li,Yang Lu,Jiake He,Shuoye Yang,Di Zhao,Xijing Chen +10 more
TL;DR: The higher absorption and slower elimination suggest that enantiopure (S)-ORC could be a promising drug that efficiently reduces clinical dosage, improves therapeutic indices, decreases toxicology risks, and results in increased therapeutic ration.
14
Optimal dosing regimen of biapenem in Chinese patients with lower respiratory tract infections based on population pharmacokinetic/pharmacodynamic modelling and Monte Carlo simulation.
Jing Dong,Wei Xiong,Yuan-cheng Chen,Yun-feng Zhao,Yang Lu,Di Zhao,Wen-yan Li,Yanhui Liu,Xijing Chen +8 more
TL;DR: A population pharmacokinetic (PPK) model of biapenem in Chinese patients with lower respiratory tract infections was developed and optimal dosage regimens based on Monte Carlo simulation were proposed, finding it may be more appropriate for combination therapy with other antibacterial agents.
14
Enantioselective HPLC determination of oxiracetam enantiomers and application to a pharmacokinetic study in beagle dogs.
Qiuyang Zhang,Wei Yang,Qing Zhang,Yue Yang,Junxiu Li,Yang Lu,Yi Zheng,Jiake He,Di Zhao,Xijing Chen +9 more
TL;DR: An enantioselective high-performance liquid chromatography method was developed and validated for the determination of oxiracetam enantiomers, a cognition and memory enhancer, in beagle dog plasma and was successfully applied to a pharmacokinetic study of individual enantiomer and racemic oxir acetam in beagles dogs after oral administration.
12
Inhibitory Effects of Calf Thymus DNA on Metabolism Activity of CYP450 Enzyme in Human Liver Microsomes
TL;DR: The findings indicated that when the medical agents catalyzed mainly by CYP2C9 were co-administered in vivo with adsorptive material in vitro, the potential inhibitory effect of ctDNA on enzyme activity and the following metabolism character changes of the former should be highly focused on.
7
Pharmacokinetic effects of curcumin on docetaxel mediated by OATP1B1, OATP1B3 and CYP450s
Xiaolin Sun,Junxiu Li,Chaorui Guo,Han Xing,Jie Xu,Yanli Wen,Zhixia Qiu,Qiuyang Zhang,Yi Zheng,Xijing Chen,Di Zhao +10 more
TL;DR: The preclinical and clinical improved docetaxel's therapeutic efficacy when co-administrated withCurcumin may be due to the inhibition of curcumin on OATP1B1, OATp1B3 and HLMs activities.