Xiaoyun Wang
University of California, San Diego
5 Papers
11 Citations
Xiaoyun Wang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Population & Massive parallel sequencing. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Xiaoyun Wang include University of California, Berkeley & Scripps Research Institute.
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Papers
Evaluation of next generation sequencing platforms for population targeted sequencing studies
Olivier Harismendy,Pauline C. Ng,Robert L. Strausberg,Xiaoyun Wang,Timothy B. Stockwell,Karen Beeson,Nicholas J. Schork,Sarah S. Murray,Eric J. Topol,Samuel Levy,Kelly A. Frazer +10 more
TL;DR: This study analyzed human sequence generated by the Roche 454, Illumina GA, and the ABI SOLiD technologies for the same 260 kb in four individuals to provide important insights into systematic biases and data variability that need to be considered when utilizing NGS platforms for population targeted sequencing studies.
Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level
Olivier Harismendy,Vikas Bansal,Gaurav Bhatia,Masakazu Nakano,Mike Scott,Xiaoyun Wang,Colette Dib,Edouard Turlotte,Jack C. Sipe,Sarah S. Murray,Jean-François Deleuze,Vineet Bafna,Eric J. Topol,Eric J. Topol,Kelly A. Frazer +14 more
TL;DR: This study, which is one of the first reports of a sequence-based association study using next-generation sequencing of candidate genes, provides insights into study design and analysis approaches and demonstrates the importance of examining regulatory elements rather than exclusively focusing on exon sequences.
Whole Transcriptome Sequencing Enables Discovery and Analysis of Viruses in Archived Primary Central Nervous System Lymphomas
Christopher DeBoever,Erin Reid,Erin N. Smith,Xiaoyun Wang,Wilmar Dumaop,Olivier Harismendy,Dennis A. Carson,Douglas D. Richman,Eliezer Masliah,Kelly A. Frazer +9 more
TL;DR: The ability of next generation transcriptome sequencing to accurately identify viruses, including DNA viruses, in solid human cancer tissue samples is demonstrated.
Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens
Shawn Yost,Erin N. Smith,Richard Schwab,Lei Bao,Hyunchul Jung,Xiaoyun Wang,Emile Voest,John P. Pierce,Karen Messer,Barbara A. Parker,Olivier Harismendy,Kelly A. Frazer +11 more
TL;DR: This study demonstrates the feasibility of performing genome-wide deep sequencing analysis of FFPE archived tumors of limited sample size such as residual cancer after treatment or metastatic biopsies and results in a breast cancer mutational profile consistent with previous studies and revealing potentially important functional mutations.
Enrichment of sequencing targets from the human genome by solution hybridization
Ryan Tewhey,Ryan Tewhey,Masakazu Nakano,Masakazu Nakano,Xiaoyun Wang,Xiaoyun Wang,Carlos Pabón-Peña,Barbara Novak,A. Giuffre,Eric Lin,Scott Happe,Doug N Roberts,Emily M LeProust,Eric J. Topol,Olivier Harismendy,Olivier Harismendy,Kelly A. Frazer,Kelly A. Frazer +17 more
TL;DR: It is demonstrated that the tiling probe frequency is important for generating sequence data with high uniform coverage of targets, and 93% sensitivity to detect SNPs, with a calling accuracy greater than 99%.