Xiaoyu Shen
Novartis
12 Papers
41 Citations
Xiaoyu Shen is an academic researcher from Novartis. The author has contributed to research in topics: Chemistry & Uncompetitive inhibitor. The author has an hindex of 8, co-authored 12 publications.
Chat about Author
Papers
Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones
Stefan Peukert,Yingchuan Sun,Rui Zhang,Brian Hurley,Michael Sabio,Xiaoyu Shen,Christen Gray,JoAnn Dzink-Fox,Jianshi Tao,Regina E. Cebula,Sompong Wattanasin +10 more
TL;DR: Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-car boxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents.
91
The Mevalonate Pathway of Staphylococcus aureus
TL;DR: It is demonstrated that decreased expression of the mevalonate pathway leads to widespread downregulation of primary metabolism genes, an upregulation in virulence factors and cell wall biosynthesis determinants, and surprisingly little compensatory expression in other isoprenoid biosynthetic genes.
64
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
Folkert Reck,Alun Bermingham,Johanne Blais,Vladimir Capka,Taryn Cariaga,Anthony Casarez,Richard Colvin,Charles R. Dean,Alex Fekete,Wanben Gong,Ellie Growcott,Hongqiu Guo,Adriana K. Jones,Cindy Li,Fengxia Li,Xiaodong Lin,Mika Lindvall,Sara Lopez,David McKenney,Louis E. Metzger,Heinz E. Moser,Ramadevi Prathapam,Dita M. Rasper,Patrick J Rudewicz,Vijay Sethuraman,Xiaoyu Shen,Jacob Shaul,Robert Lowell Simmons,Kyuto Tashiro,Dazhi Tang,Meiliana Tjandra,Nancy Turner,Tsuyoshi Uehara,Charles Vitt,Steven Whitebread,Aregahegn Yifru,Xu Zang,Qingming Zhu +37 more
TL;DR: Novel monobactams are optimized for stability against SBLs, which led to the identification of LYS228, which is potent in the presence of all classes of β-lactamases and shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae (CRE).
54
IID572: A New Potentially Best-In-Class β-Lactamase Inhibitor.
Folkert Reck,Alun Bermingham,Johanne Blais,Anthony Casarez,Richard Colvin,Charles R. Dean,Markus Furegati,Luis Gamboa,Ellena Growcott,Cindy Li,Sara Lopez,Louis E. Metzger,Sandro Nocito,Flavio Ossola,Kaci Phizackerley,Dita M. Rasper,Jacob Shaul,Xiaoyu Shen,Robert Lowell Simmons,Dazhi Tang,Kyuto Tashiro,Qin Yue +21 more
TL;DR: IID572 is a novel broad spectrum BLI of the diazabicyclooctane (DBO) class that is able to restore the antibacterial activity of p Piperacillin against piperacillin/tazobactam-resistant clinical isolates.
23
Determinants of Antibacterial Spectrum and Resistance Potential of the Elongation Factor G Inhibitor Argyrin B in Key Gram-Negative Pathogens.
Adriana K. Jones,Angela L. Woods,Kenneth T. Takeoka,Xiaoyu Shen,Jun-Rong Wei,Ruth E. Caughlan,Charles R. Dean +6 more
TL;DR: Argyrins are natural products with antibacterial activity against Gram-negative pathogens, such as Pseudomonas aeruginosa, Burkholderia multivorans, and Stenotrophomonas maltophilia, and it is shown that argyrin B targets elongation factor G (FusA) and activity against P. baumannii was inactive and resistance occurred at high frequency through loss of the sensitive FusA1.
20