Xiaoying Fu
Okayama University
5 Papers
15 Citations
Xiaoying Fu is an academic researcher from Okayama University. The author has contributed to research in topics: Cancer stem cell & Induced pluripotent stem cell. The author has an hindex of 2, co-authored 5 publications. Previous affiliations of Xiaoying Fu include Tianjin University of Traditional Chinese Medicine.
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Papers
Chronic exposure to FGF2 converts iPSCs into cancer stem cells with an enhanced integrin/focal adhesion/PI3K/AKT axis.
Mona Sheta,Mona Sheta,Ghmkin Hassan,Ghmkin Hassan,Said M. Afify,Said M. Afify,Sadia Monzur,Kazuki Kumon,Hagar A. Abu Quora,Mahmoud Farahat,Maram H. Zahra,Xiaoying Fu,Xiaoying Fu,Akimasa Seno,Masaharu Seno +14 more
TL;DR: In this article, a meta-analysis was conducted to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion and found that fibroblast growth factor 2 (FGF2) was the best candidate in T47D and BT549 cells, of which conditioned medium was previously successful in inducing CSCs.
22
•Journal Article
Upregulated CCL20 and CCR6 in Cancer Stem Cells Converted from Mouse iPS Cells
Juan Du,Akimasa Seno,Saki Sasada,Yanning Xu,Aung Ko Ko Oo,Ghmkin Hassan,Shunsuke Ueno,Said M. Afify,Maram H Zahra,Nobuhiro Okada,Ling Chen,Xiaoying Fu,Heizo Tokutaka,Ting Yan,Masaharu Seno +14 more
TL;DR: A model of CSCs with CCL20-CCR6 autocrine loop was obtained as the result of the conversion of iPSCs, and this CSC should be a good model to study targeting CCR6 as a G protein-coupled receptor (GPCR).
•Journal Article
Microenvironment of mammary fat pads affected the characteristics of the tumors derived from the induced cancer stem cells.
Hagar A. Abu Quora,Hagar A. Abu Quora,Maram H. Zahra,Samah El-Ghlban,Neha Nair,Said M. Afify,Said M. Afify,Ghmkin Hassan,Hend M. Nawara,Mona Sheta,Sadia Monzur,Xiaoying Fu,Xiaoying Fu,Amira Osman,Akimasa Seno,Masaharu Seno +15 more
TL;DR: In this article, a breast cancer tumor model was established using mouse induced pluripotent stem cells developed from normal fibroblasts without genetic manipulation, which were transplanted into the mammary fat pads of BALB/c nude mice, these two model cells formed malignant tumors exhibiting pronounced histopathological characteristics similar to breast cancers.
2
Revisiting Cancer Stem Cells as the Origin of Cancer-Associated Cells in the Tumor Microenvironment: A Hypothetical View from the Potential of iPSCs
Amira Osman,Said M. Afify,Ghmkin Hassan,Ghmkin Hassan,Xiaoying Fu,Xiaoying Fu,Akimasa Seno,Akimasa Seno,Masaharu Seno,Masaharu Seno +9 more
TL;DR: It is postulated that cancer stem cells (CSCs) could be one of the key sources of CAFs, TECs, TAAs, and TAMs as well as the descendants, which support the self-renewal potential of the cells and exhibit heterogeneity.
Tumor-associated macrophages derived from cancer stem cells
Amira Osman,Amira Osman,Miharu Oze,Said M. Afify,Said M. Afify,Ghmkin Hassan,Ghmkin Hassan,Samah El-Ghlban,Samah El-Ghlban,Hend M. Nawara,Xiaoying Fu,Xiaoying Fu,Maram H. Zahra,Akimasa Seno,Akimasa Seno,Ira Winer,David S. Salomon,Masaharu Seno,Masaharu Seno +18 more
TL;DR: This may be the first study to suggest the potential differentiation of CSCs to TAMs and the localization and the origin of tumor-associated macrophages (TAMs), according to the best of the authors' knowledge.