Xiaoxiang Guan
Nanjing Medical University
92 Papers
397 Citations
Xiaoxiang Guan is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Breast cancer & Triple-negative breast cancer. The author has an hindex of 25, co-authored 70 publications. Previous affiliations of Xiaoxiang Guan include University of Texas at Austin & University of Texas MD Anderson Cancer Center.
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Papers
Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis.
Yucai Wang,Shouhao Zhou,Shouhao Zhou,Fang Yang,Xinyue Qi,Xin Wang,Xiaoxiang Guan,Xiaoxiang Guan,Chan Shen,Narjust Duma,Jesus Vera Aguilera,Ashish V. Chintakuntlawar,Katharine A. Price,Julian R. Molina,Lance C. Pagliaro,Thorvardur R. Halfdanarson,Axel Grothey,Axel Grothey,Svetomir N. Markovic,Grzegorz S. Nowakowski,Stephen M. Ansell,Michael L. Wang +21 more
TL;DR: Different PD-1 and PD-L1 inhibitors appear to have varying treatment-related adverse events; a comprehensive summary of the incidences of treatment- related adverse events in clinical trials provides an important guide for clinicians.
Correction: Corrigendum: PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer
TL;DR: This Article contains an error in Figure 4A where the graphs were labelled incorrectly and the correct figure appears below as Figure 1.
Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis.
Kun Xu,Runtian Wang,Hui Xie,Longfei Hu,Cong Wang,Jiali Xu,Chengjun Zhu,Yiqiu Liu,Fangyan Gao,Xintong Li,Cenzhu Wang,Jinyi Huang,Wenbin Zhou,Guohua Zhou,Yongqian Shu,Xiaoxiang Guan +15 more
- 05 Oct 2021
TL;DR: In this article, the authors investigated the transcriptome profile of 96,796 single cells from 15 paired samples of primary tumors and axillary lymph nodes and found that NECTIN2-TIGIT-mediated interactions between metastatic breast cancer cells and tumor microenvironment (TME) cells promoted immune escape and lymph node metastasis.
Therapeutic landscape in mutational triple negative breast cancer.
TL;DR: The germline and somatic mutation profiles of TNBC are summarized and the current and upcoming therapeutic strategies targeting the mutant proteins or pathways to enable tailored-therapeutics are discussed.
Integrative analyses of scRNA-seq and scATAC-seq reveal CXCL14 as a key regulator of lymph node metastasis in breast cancer.
Kun Xu,Wenwen Zhang,Cong Wang,Longfei Hu,Runtian Wang,Cenzhu Wang,Lin Tang,Guohua Zhou,Bingjie Zou,Hui Xie,Jinhai Tang,Xiaoxiang Guan +11 more
TL;DR: In this article, the authors employed single-cell RNA sequencing to acquire the transcriptomic profiles of individual cells from primary tumors, negative lymph nodes (NLs) and positive lymph nodes(PLs).
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