Xiaoting Sun
Shanghai University
7 Papers
20 Citations
Xiaoting Sun is an academic researcher from Shanghai University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Xiaoting Sun include Karolinska Institutet.
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Papers
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
Hideki Iwamoto,Hideki Iwamoto,Mitsuhiko Abe,Mitsuhiko Abe,Yunlong Yang,Dongmei Cui,Takahiro Seki,Masaki Nakamura,Kayoko Hosaka,Sharon Lim,Jieyu Wu,Xingkang He,Xiaoting Sun,Xiaoting Sun,Yongtian Lu,Qingjun Zhou,Weiyun Shi,Takuji Torimura,Guohui Nie,Qi Li,Yihai Cao +20 more
TL;DR: An effective cancer therapy concept is proposed by combining drugs that target angiogenesis and lipid metabolism, and genetic and pharmacological loss of CPT1 function sensitizes AAD therapeutic efficacy and enhances its anti-tumor effects.
240
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism.
Xiaoting Sun,Xingkang He,Yin Zhang,Kayoko Hosaka,Patrik Andersson,Jing Wu,Jieyu Wu,Xu Jing,Qiqiao Du,Xiaoli Hui,Bo Ding,Ziheng Guo,An Hong,Xuan Liu,Yan Wang,Qing Ji,Rudi Beyaert,Yunlong Yang,Qi Li,Yihai Cao +19 more
TL;DR: In this paper, the role of the IL-33-ST2-CXCL3−CXCR2 axis in PDAC metastasis was evaluated in three clinically relevant mouse PDAC models.
173
Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors.
Kayoko Hosaka,Yunlong Yang,Yunlong Yang,Takahiro Seki,Takahiro Seki,Qiqiao Du,Xu Jing,Xu Jing,Xingkang He,Jieyu Wu,Yin Zhang,Yin Zhang,Hiromasa Morikawa,Masaki Nakamura,Masaki Nakamura,Martin Scherzer,Xiaoting Sun,Xiaoting Sun,Yuanfu Xu,Tao Cheng,Xuri Li,Xialin Liu,Qi Li,Yizhi Liu,An Hong,Yuguo Chen,Yihai Cao +26 more
TL;DR: It is demonstrated that the dual-targeting of VEGF and PDGF is required for targeting resistant FGF2+ tumors which depend on the recruitment of pericytes on tumor microvessels through a PDGFRβ-dependent mechanism.
Fat Wasting Is Damaging: Role of Adipose Tissue in Cancer-Associated Cachexia.
TL;DR: The role of adipose tissue in CAC development, mechanism, and therapy is discussed and mechanisms that may ultimately be translated into future therapeutic possibilities that benefit CAC patients are discussed.
56
p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma
TL;DR: It is found that, unlike in other cancer types, p38α is significantly activated in pancreatic adenocarcinoma samples, suggesting its potential for anti-pancreatic cancer therapy and reveal potential catalysis mechanism involving a “butterfly” motion.