Xiaotian Ju
McMaster University
13 Papers
2 Citations
Xiaotian Ju is an academic researcher from McMaster University. The author has contributed to research in topics: Medicine & Innate lymphoid cell. The author has an hindex of 2, co-authored 3 publications.
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Papers
The Role of the TL1A/DR3 Axis in the Activation of Group 2 Innate Lymphoid Cells in Subjects with Eosinophilic Asthma.
Kentaro Machida,Michael Aw,Brittany M. Salter,Xiaotian Ju,Manali Mukherjee,Gail M. Gauvreau,Paul M. O'Byrne,Parameswaran Nair,Roma Sehmi +8 more
TL;DR: The TL1A/DR3 axis is a co-stimulator of ILC2s in asthma, particularly in the airways of patients with a predisposition to autoimmune responses, and the highest levels detected in severe asthmatics with airway autoimmune responses.
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Eosinophil Lineage-Committed Progenitors as a Therapeutic Target for Asthma
TL;DR: In this article, a review of the role of EoP in asthma and discusses findings from clinical trials with various therapeutic targets is presented. But, they do not show that targeting single mediators downstream of the inflammatory cascade may not fully attenuate tissue eosinophilia due to the multiplicity of factors that can promote tissue eoophilia.
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Benralizumab Normalizes Sputum Eosinophilia in Severe Asthma Uncontrolled by Anti-IL5 Antibodies: A Single-Blind, Placebo-controlled Clinical Trial.
A. Mukherjee,Chynna Margaret Huang,C. Venegas-Garrido,Kayla Zhang,Anurag Bhalla,Xiaotian Ju,Paul M O'Byrne,Sarah Svenningsen,Roma Sehmi,Parameswaran Nair +9 more
TL;DR: Benralizumab, a monoclonal antibody, normalizes sputum eosinophilia in severe asthma patients uncontrolled by anti-IL-5 antibodies, demonstrating its efficacy in a single-blind, placebo-controlled clinical trial.
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Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma.
Xiaotian Ju,Akimichi Nagashima,Anna Dvorkin-Gheva,Jennifer Wattie,Karen Howie,Christiane Whetstone,Maral Ranjbar,Ruth P Cusack,Reina Ditta,Guillaume Paré,Imran Satia,Paul M O'Byrne,Gail M Gauvreau,Roma Sehmi +13 more
TL;DR: The NMU/NMUR1 axis stimulates rapid effects on ILC2, and maybe an important early activator of these cells in eosinophilic inflammatory responses in asthma.
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Evaluation of the reproducibility of responses to nasal allergen challenge and effects of inhaled nasal corticosteroids.
Rebecca N Bauer,Yanqing Xie,Suzanne Beaudin,Lesley Wiltshire,Jennifer Wattie,Caroline Munoz,N. Alsaji,John-Paul Oliveria,Xiaotian Ju,Jonathan MacLean,Doron D. Sommer,Paul K Keith,Imran Satia,Ruth Cusack,Paul M O'Byrne,Gizette Sperinde,Martha Hokom,O. Li,Prajna Banerjee,Chen Chen,Tracy Staton,Roma Sehmi,Gail M. Gauvreau +22 more
TL;DR: NAC-induced biomarkers and symptoms are reproducible and responsive to INCS. NAC is a suitable model for assessing drug efficacy in allergic rhinitis and asthma.
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