Xiaoti Guo
University of Virginia
12 Papers
324 Citations
Xiaoti Guo is an academic researcher from University of Virginia. The author has contributed to research in topics: Entamoeba histolytica & Leptin receptor. The author has an hindex of 11, co-authored 12 publications. Previous affiliations of Xiaoti Guo include National Institutes of Health.
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Papers
Vaccines to combat the neglected tropical diseases.
Jeffrey M. Bethony,Rhea N. Cole,Xiaoti Guo,Shaden Kamhawi,Marshall W. Lightowlers,Alex Loukas,William A. Petri,Steven G. Reed,Jesus G. Valenzuela,Peter J. Hotez +9 more
TL;DR: The current status of scientific and technical progress in the development of new neglected tropical disease vaccines is reviewed, highlighting the successes that have been achieved (cysticercosis and echinococcosis) and identifying the challenges and opportunities forDevelopment of new vaccines for NTDs.
Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica
Xiaoti Guo,Margo R. Roberts,Stephen M. Becker,Bradley S. Podd,Yiying Zhang,Streamson C. Chua,Martin G. Myers,Priya Duggal,Eric R. Houpt,William A. Petri +9 more
TL;DR: It is concluded that leptin-mediated resistance to amebiasis is via its actions on intestinal epithelium rather than hematopoietic cells or the brain, and requires leptin receptor signaling through both the STAT3 and SHP2/ERK pathways.
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Persistence of Entamoeba histolytica infection in CBA mice owes to intestinal IL-4 production and inhibition of protective IFN-gamma
TL;DR: It is indicated that IL-4 plays a critical pathogenic role in the persistence of E. histolytica infection through suppression of protective IFN-γ and provide a possible explanation for why certain humans spontaneously clear amebiasis while others progress to invasive disease.
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The expression of REG 1A and REG 1B is increased during acute amebic colitis
Kristine M. Peterson,Xiaoti Guo,Abdel G. Elkahloun,Dinesh Mondal,Pradip Kumar Bardhan,Akira Sugawara,Priya Duggal,Rashidul Haque,William A. Petri +8 more
TL;DR: REG 1A and REG 1B were upregulated during amebiasis and may function to protect the intestinal epithelium from parasite-induced apoptosis, and were the most up-regulated of all genes in the human intestine in acute versus convalescent E. histolytica disease.
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Protection against Intestinal Amebiasis by a Recombinant Vaccine Is Transferable by T Cells and Mediated by Gamma Interferon
Xiaoti Guo,Lisa Barroso,Steven M. Becker,David M. Lyerly,Thomas S. Vedvick,Steven G. Reed,William A. Petri,Eric R. Houpt +7 more
TL;DR: It is demonstrated with adoptive-transfer experiments that CMI is sufficient for vaccine protection from intestinal amebiasis and reveal an important role for IFN-γ, even in the setting of alum.
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