One-pot formation of six bonds: pseudo-six-component diastereoselective synthesis of pyridinium-containing piperidin-2-ones

Pyridines and benzo derivatives are important classes of heterocyclic compounds that have attracted significant attention due to their diverse chemical and biological properties. This review covers recent developments in the synthesis of these compounds during the year 2022, including new methods for functionalization and modification of their structures. It also highlights the potential of these compounds as versatile building blocks for the design of novel compounds with desired properties in various fields, including drug discovery, agrochemicals, materials science, and catalysis. 

Six-membered ring systems: pyridines and benzo derivatives

A facile route for direct access to the 4-iodopyrrole-2-carbaldehydes from pyridinium salts has been successfully developed, which undergoes cascade pyrrole-2-carbaldehydes construction/selective C4 position iodination process. Using Na2S2O8 as an oxidant and readily available sodium iodide as an iodine source, a variety of 4-iodopyrrole-2-carbaldehydes were obtained in good to excellent yields. Atom- and step-economy, good functional group tolerance, high regioselectivity, as well as mild conditions entail this transformation an alternative strategy for enriching pyrroles library.

Tandem Ring-Contraction/Regioselective C-H Iodination Reaction of Pyridinium Salts.

A rhodaelectro-catalyzed double dehydrogenative Heck reaction of indole-2-carboxylic acids with alkenes has been developed for the synthesis of pyrano[3,4- 

Rhodaelectro-Catalyzed Synthesis of Pyrano[3,4-b]indol-1(9H)-ones via the Double Dehydrogenative Heck Reaction between Indole-2-carboxylic Acids and Alkenes

The first catalytic protocol for regioselective [3+2] annulation of N-methyl pyridinium ylides with alkenes to establish various valuable 3-unsubstituted indolizine derivatives is accomplished by palladium catalysis in the unactivated position....

Regioselective Annulation of N-Methylpyridinium Ylides with Alkenes Enabled by Palladium Catalysis: Access to 3-Unsubstituted Indolizine Derivatives

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Regioselective Annulation of N-Methylpyridinium Ylides with Alkenes Enabled by Palladium Catalysis: Access to 3-Unsubstituted Indolizine Derivatives