Xiaoping Jiang

TL;DR: It is demonstrated that subcutaneous ZIKV infection can protect against subsequent vaginal infection by generating both local antiviral T cell and antibody responses.

TL;DR: In this article, sustained type I IFN signaling is a driver of pathogenic neutrophil responses, and identifies IL-18 as a novel component of disease during genital HSV-2 infection.

TL;DR: It is shown that vaginal infection of mice with HSV-1 leads to the rapid appearance of mature DCs in the draining lymph node, which is dependent on an early burst of NK cell-mediated IFN-γ production in the vagina that occurs after HSV -1 infection but notHSV-2 infection.

TL;DR: Lebratti et al. as discussed by the authors found that a signaling molecule called type I interferon, which is thought to be antiviral, causes neutrophils at the site of the infection to produce proteins such as IL-18, which trigger an inflammatory reaction.