Xiaoping Chen
Northwestern University
26 Papers
56 Citations
Xiaoping Chen is an academic researcher from Northwestern University. The author has contributed to research in topics: Biology & Neurodegeneration. The author has an hindex of 17, co-authored 23 publications.
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Papers
An ALS-associated Mutation Affecting TDP-43 Enhances Protein Aggregation, Fibril Formation and Neurotoxicity
Weirui Guo,Yanbo Chen,Xiaohong Zhou,Amar N. Kar,Amar N. Kar,Payal Ray,Xiaoping Chen,Elizabeth J. Rao,Mengxue Yang,Haihong Ye,Li Zhu,Jianghong Liu,Meng Xu,Yanlian Yang,Chen Wang,David Luowei Zhang,Eileen H. Bigio,M.-Marsel Mesulam,Yan Shen,Qi Xu,Kazuo Fushimi,Jane Y. Wu +21 more
TL;DR: Comparing wild-type and an ALS-associated mutant TDP-43 in vitro and in vivo provides evidence for biochemical similarities between TPD-43 and prion proteins, raising the possibility that T DP-43 derivatives may cause spreading of the disease phenotype among neighboring neurons.
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A Drosophila model for TDP-43 proteinopathy
Yan Li,Payal Ray,Elizabeth J. Rao,Chen Shi,Chen Shi,Weirui Guo,Xiaoping Chen,Elvin A. Woodruff,Kazuo Fushimi,Jane Y. Wu +9 more
TL;DR: Transgenic flies expressing hTDP-43 recapitulate important neuropathological and clinical features of human TDP- 43 proteinopathy, providing a powerful animal model for this group of devastating diseases.
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
Peng Wang,Jianwen Deng,Jie Dong,Jianghong Liu,Eileen H. Bigio,M.-Marsel Mesulam,Tao Wang,Lei Sun,Li Wang,Alan Yueh Luen Lee,Warren A. McGee,Xiaoping Chen,Kazuo Fushimi,Li Zhu,Jane Y. Wu,Jane Y. Wu +15 more
TL;DR: It is suggested that blocking or reversing mitochondrial damage may provide a potential therapeutic approach to these devastating diseases and uncovered a previously unknown role of LonP1 in regulating mitochondrial TDP-43 levels, but also advanced the understanding of the pathogenic mechanisms for T DP-43 proteinopathy.
FUS Interacts with HSP60 to Promote Mitochondrial Damage
Jianwen Deng,Mengxue Yang,Yanbo Chen,Xiaoping Chen,Jianghong Liu,Shufeng Sun,Haipeng Cheng,Yang Li,Eileen H. Bigio,M.-Marsel Mesulam,Qi Xu,Sidan Du,Kazuo Fushimi,Li Zhu,Jane Y. Wu +14 more
TL;DR: Evidence for mitochondrial localization of FUS and its induction of mitochondrial damage is provided and mitochondrial damage may be a target in future development of diagnostic and therapeutic tools for FUS-proteinopathies, a group of devastating neurodegenerative diseases.
Expression of human FUS protein in Drosophila leads to progressive neurodegeneration
Yanbo Chen,Mengxue Yang,Jianwen Deng,Xiaoping Chen,Ye Ye,Li Zhu,Jianghong Liu,Haihong Ye,Yan Shen,Yan Li,Yan Li,Elizabeth J. Rao,Elizabeth J. Rao,Kazuo Fushimi,Xiaohong Zhou,Eileen H. Bigio,M.-Marsel Mesulam,Qi Xu,Jane Y. Wu,Jane Y. Wu +19 more
TL;DR: The transgenic flies expressing the hFUS gene recapitulate key features of FUS proteinopathy, representing the first stable animal model for this group of devastating diseases.