Xiaoming Ju
Thomas Jefferson University
26 Papers
39 Citations
Xiaoming Ju is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Cyclin D1 & Cyclin D. The author has an hindex of 20, co-authored 26 publications. Previous affiliations of Xiaoming Ju include Georgetown University.
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Papers
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
Zuoren Yu,Chenguang Wang,Min Wang,Zhiping Li,Mathew C. Casimiro,Manran Liu,Kongming Wu,James R. Whittle,Xiaoming Ju,Terry Hyslop,Peter McCue,Richard G. Pestell +11 more
TL;DR: These studies identify a novel cyclin D1/miR-17/20 regulatory feedback loop through which cyclinD1 induces miR- 17-5p/mi R-20a and limits the proliferative function of cyclIn D1, thus linking expression of a specific miRNA cluster to the regulation of oncogenesis.
Akt1 governs breast cancer progression in vivo
Xiaoming Ju,Sanjay Katiyar,Chenguang Wang,Manran Liu,Xuanmao Jiao,Shengwen Li,Jie Zhou,Jacob Turner,Michael P. Lisanti,Robert G. Russell,Susette C. Mueller,John O. Ojeifo,William S. Chen,Nissim Hay,Richard G. Pestell +14 more
TL;DR: Disruption of the ubiquitously expressed member of the Akt family of genes, Akt1, in the mouse demonstrates a requirement forAkt1 in ErbB2-induced mammary tumorigenesis and governs MEC polarity, migratory directionality and breast cancer onset induced by Erb B2 in vivo.
209
p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo
Manran Liu,Mathew C. Casimiro,Chenguang Wang,L. Andrew Shirley,Xuanmao Jiao,Sanjay Katiyar,Xiaoming Ju,Zhiping Li,Zuoren Yu,Jie Zhou,Michael D. Johnson,Paolo Fortina,Terry Hyslop,Jolene J. Windle,Richard G. Pestell +14 more
TL;DR: A link between the loss of p21CIP1 and the acquisition of breast cancer EMT and stem cell properties in vivo is established.
180
CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene-Transformed Metastatic Prostate Cancer Cell Lines
Daniela Sicoli,Xuanmao Jiao,Xiaoming Ju,Marco A. Velasco-Velázquez,Adam Ertel,Sankar Addya,Zhiping Li,Sebastiano Andò,Alessandro Fatatis,Bishnuhari Paudyal,Massimo Cristofanilli,Mathew L. Thakur,Michael P. Lisanti,Richard G. Pestell +13 more
TL;DR: To determine the molecular mechanisms governing prostate cancer bone metastasis, FVB murine prostate epithelium was transduced with oncogenic v-Src andGene expression profiling of the tumors identified activation of a CCR5 signaling module when the prostate epithelial cell lines were grown in vivo versus tissue cultures.
77
Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage
Francesco Marampon,Francesco Marampon,Giovanni Luca Gravina,Xiaoming Ju,Antonella Vetuschi,Roberta Sferra,Mathew C. Casimiro,Simona Pompili,Claudio Festuccia,Alessandro Colapietro,Eugenio Gaudio,Ernesto Di Cesare,Vincenzo Tombolini,Richard G. Pestell +13 more
TL;DR: Observations suggest that CCND1 is a key mediator of PCa radioresistance and could represent a potential target for radioresistant hormone-resistant PCa.