Xiaomin Lai
Sun Yat-sen University
8 Papers
26 Citations
Xiaomin Lai is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: T-cell receptor & ELISPOT. The author has an hindex of 6, co-authored 8 publications.
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Papers
MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb
Jinli Wang,Kun Yang,Lin Zhou,MinhaoWu,Yongjian Wu,Min Zhu,Xiaomin Lai,Tao Chen,Lianqiang Feng,Meiyu Li,Chunyu Huang,Qiu Zhong,Xi Huang +12 more
TL;DR: The results reveal a novel role of miR-155 in regulating autophagy-mediated mycobacterial elimination by targeting Rheb, and provide potential targets for clinical treatment.
microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production
Miao Li,Miao Li,Jinli Wang,Jinli Wang,Jinli Wang,Yimin Fang,Sitang Gong,Meiyu Li,Meiyu Li,Minhao Wu,Minhao Wu,Xiaomin Lai,Gucheng Zeng,Yi Wang,Yi Wang,Kun Yang,Kun Yang,Xi Huang,Xi Huang +18 more
TL;DR: A novel role of miR-146a is demonstrated in the modulation of host defense against mycobacterial infection by repressing NO production via targeting TRAF6, which may provide a promising therapeutic target for tuberculosis.
Use of HLA-DR*08032/E7 and HLA-DR*0818/E7 tetramers in tracking of epitope-specific CD4+ T cells in active and convalescent tuberculosis patients compared with control donors.
Yan Li,Yan Zhu,Lin Zhou,Yimin Fang,Lirong Huang,Liangliang Ren,Yi Peng,Yifen Li,Fangfang Yang,Dan Xie,Wenzheng Tang,Na Zhang,Qiu Zhong,Xiaomin Lai +13 more
TL;DR: By further increasing the sample size tested to confirm the specificity and sensitivity of tetrameric molecules, it should be possible to develop them for use as research and diagnostic reagents.
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Corrigendum: microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production
Miao Li,Jinli Wang,Yimin Fang,Sitang Gong,Meiyu Li,Minhao Wu,Xiaomin Lai,Gucheng Zeng,Yi Wang,Kun Yang,Xi Huang +10 more
TL;DR: This Article contains typographical errors in a grant number in the Acknowledgements section and should read: “This work was supported by grants National Natural Science Foundation of China (31470877, 81172811).”
Relatively low level of antigen-specific monocytes detected in blood from untreated tuberculosis patients using CD4+ T-cell receptor tetramers.
Yuhong Huang,Yan Huang,Yimin Fang,Juan Wang,Yan Li,Nan Wang,Jianbo Zhang,Ming Gao,Lirong Huang,Fangfang Yang,Cong Wang,Shu-Xian Lin,Yanan Yao,Liangliang Ren,Yi Chen,Xuanjing Du,Dan Xie,Rongshun Wu,Kouxing Zhang,Lifang Jiang,Xinbing Yu,Xiaomin Lai +21 more
TL;DR: Results suggest that there is a relatively low level of MTB-specific monocytes in advanced and untreated patients, and show that MTB induces apoptosis in CD14+ cells, and the percentage of apoptotic monocytes dramatically decreases after treatment.