Xiaomin Fan
9 Papers
53 Citations
Xiaomin Fan is an academic researcher. The author has contributed to research in topics: Viral load & Antibody. The author has an hindex of 4, co-authored 9 publications.
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Papers
A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters.
Anna C. Fagre,John Manhard,Rachel Adams,Miles Eckley,Shijun Zhan,Juliette Lewis,Savannah M. Rocha,Catherine Woods,Karina Kuo,Wuxiang Liao,Lin Li,Adam Corper,Dilip Challa,Emily Mount,Christine Tumanut,Ronald B. Tjalkens,Tawfik A. Aboellail,Xiaomin Fan,Tony Schountz +18 more
TL;DR: A panel of human monoclonal antibody clones from a yeast display library with specificity to the SARS-CoV-2 spike protein receptor binding domain that neutralized the virus in vitro was identified and could provide an important therapy for treatment of COVID-19 patients.
An in vivo approach to structure activity relationship analysis of peptide ligands.
Xiaomin Fan,Ruben Venegas,Robert A. Fey,Henri C. van der Heyde,Mark A. Bernard,Elias Lazarides,Catherine M. Woods +6 more
TL;DR: Incorporating normal blood phamacokinetics of T7 phage into in vivo phage display improves the ability to recover targeting peptide motifs and allows effective lead optimization by kSAR.
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Synergistic Effect of AJW200, a von Willebrand Factor Neutralizing Antibody with Low Dose (0.9 mg/mg) Thrombolytic Therapy Following Embolic Stroke in Rabbits.
TL;DR: This study shows that the concomitant administration of the anti-vWF-Ab AJW200 with low dose tPA is synergistic and results in significantly improved behavioral function following embolic stroke.
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Patent
Humanized antibodies specific for von willebrand factor
Elias Lazarides,Catherine M. Woods,Xiaomin Fan,Samuel Hou,Harald Mottl,Stanislas Blein,Martin Bertschinger +6 more
- 22 Jan 2009
TL;DR: The present disclosure relates to humanized antibodies or binding fragments thereof specific for human von Willebrand factor (vWF), methods for their preparation and use, including methods for treating vWF mediated diseases or disorders.
14
High-throughput screening and validation of antibodies against synaptic proteins to explore opioid signaling dynamics.
Mariana Lemos Duarte,Nikita A. Trimbake,Nikita A. Trimbake,Achla Gupta,Christine Tumanut,Xiaomin Fan,Catherine Woods,Akila Ram,Ivone Gomes,Erin N. Bobeck,Deborah Schechtman,Lakshmi A. Devi +11 more
- 22 Feb 2021
TL;DR: In this paper, a strategy integrating multiple state-of-the-art methods to produce, validate, and utilize antibodies was presented to examine the effect of treatment with opiates that have played central roles in the worsening of the "opioid epidemic."