Xiaoling Zhou
National Institutes of Health
8 Papers
109 Citations
Xiaoling Zhou is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Protein kinase C & Diacylglycerol kinase. The author has an hindex of 6, co-authored 8 publications.
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Papers
The adaptive imbalance in base excision–repair enzymes generates microsatellite instability in chronic inflammation
Lorne J. Hofseth,Mohammed A. Khan,Mark Ambrose,Olga Nikolayeva,Meng Xu-Welliver,Maria Kartalou,S. Perwez Hussain,Richard B. Roth,Xiaoling Zhou,Leah E. Mechanic,Irit Zurer,Varda Rotter,Leona D. Samson,Curtis C. Harris +13 more
TL;DR: In this article, the authors examined tissues from noncancerous colons of ulcerative colitis patients to determine the activity of two base excision-repair enzymes, AAG, the major 3-methyladenine DNA glycosylase, and APE1, the apurinic site endonuclease, and the prevalence of microsatellite instability.
•Journal Article
COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis.
Xiaoling Zhou,Xin Wei Wang,Lixin Xu,Koichi Hagiwara,Makoto Nagashima,Roland Wolkowicz,Irit Zurer,Varda Rotter,Curtis C. Harris +8 more
TL;DR: Data indicate that the CTD of p53 is an important component of p 53-mediated apoptosis and cell growth arrest and that inactivation of the apoptotic function, but not the inhibition of growth, is a important step during human tumorigenesis.
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WNT10B functional dualism : β-catenin /tcf -dependent growth promotion or independent suppression with deregulated expression in cancer
Hirohide Yoshikawa,Kenichi Matsubara,Xiaoling Zhou,Shu Okamura,Takahiko Kubo,Yaeko Murase,Yuko Shikauchi,Manel Esteller,James G. Herman,Xin Wei Wang,Curtis C. Harris +10 more
TL;DR: It is suggested that FGF switches WNT10B from a negative to a positive cell growth regulator, which acts synergistically with the fibroblast growth factor (FGF) to stimulate cell growth.
Inhibitory Effects of Nitric Oxide and Nitrosative Stress on Dopamine-β-Hydroxylase
Xiaoling Zhou,Michael Graham Espey,James X. Chen,Lorne J. Hofseth,Katrina M. Miranda,S. Perwez Hussain,David A. Wink,Curtis C. Harris +7 more
TL;DR: The results are consistent with the hypothesis that nitrosative stress, mediated by N2O3, can result in the inhibition of norepinephrine biosynthesis and may contribute to the regulation of neurotransmission and vasodilatation.
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Characterization of AJH-836, a diacylglycerol-lactone with selectivity for novel PKC isozymes
Mariana Cooke,Xiaoling Zhou,Victoria Casado-Medrano,Cynthia Lopez-Haber,Martin J. Baker,Rachana Garg,Jihyae Ann,Jeewoo Lee,Peter M. Blumberg,Marcelo G. Kazanietz +9 more
TL;DR: It is concluded that AJH-836 represents a C1 domain ligand with PKC-activating properties distinct from those of natural DAGs and phorbol esters, which supports the feasibility of generating selective C1domain ligands that promote novel biological response patterns.
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