Xiaoling Hu
University of Louisville
21 Papers
44 Citations
Xiaoling Hu is an academic researcher from University of Louisville. The author has contributed to research in topics: T cell & Inflammation. The author has an hindex of 12, co-authored 21 publications.
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Papers
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming.
Samantha M. Morrissey,Fan Zhang,Chuanlin Ding,Diego E. Montoya-Durango,Xiaoling Hu,Chenghui Yang,Zhen Wang,Fang Yuan,Matthew P. Fox,Huang-Ge Zhang,Haixun Guo,David Tieri,Maiying Kong,Corey T. Watson,Robert A. Mitchell,Xiang Zhang,Kelly M. McMasters,Jian Huang,Jun Yan +18 more
TL;DR: In this article, the authors demonstrate that tumor-derived exosomes polarize macrophages toward an immunosuppressive phenotype characterized by increased PD-L1 expression through NF-kB-dependent, glycolytic-dominant metabolic reprogramming.
322
A Critical Role of the IL-1β–IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis
Yihua Cai,Feng Xue,Chen Quan,Minye Qu,Na Liu,Yuan Zhang,Chris Fleming,Xiaoling Hu,Huang-Ge Zhang,Ralph R. Weichselbaum,Yang Xin Fu,David Tieri,Eric C. Rouchka,Jie Zheng,Jun Yan +14 more
TL;DR: The IL-1β-IL-1R signaling pathway may contribute to skin inflammation and psoriasis pathogenesis via the direct regulation of dermal IL-17-producing cells and stimulation of keratinocytes for amplifying inflammatory cascade.
221
Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype
Min Liu,Min Liu,Fengling Luo,Fengling Luo,Chuanlin Ding,Sabrin Albeituni,Xiaoling Hu,Yunfeng Ma,Yihua Cai,Lacey R. McNally,Mary Ann Sanders,Dharamvir Jain,Goetz Kloecker,Michael Bousamra,Huang-Ge Zhang,Richard M. Higashi,Andrew N. Lane,Teresa W.-M. Fan,Jun Yan +18 more
TL;DR: It is demonstrated that particulate yeast-derived β-glucan, a natural polysaccharide compound, converts polarized alternatively activated macrophages or immunosuppressive TAM into a classically activated phenotype with potent immunostimulating activity.
155
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer
Min Liu,Zan Tong,Chuanlin Ding,Fengling Luo,Shouzhen Wu,Caijun Wu,Sabrin Albeituni,Liqing He,Xiaoling Hu,David Tieri,Eric C. Rouchka,Michito Hamada,Satoru Takahashi,Andrew A. Gibb,Goetz Kloecker,Huang-Ge Zhang,Michael Bousamra,Bradford G. Hill,Xiang Zhang,Jun Yan +19 more
TL;DR: It is demonstrated that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in cancer and a potential target for effective tumor immunotherapy.
Yeast-Derived Particulate β-Glucan Treatment Subverts the Suppression of Myeloid-Derived Suppressor Cells (MDSC) by Inducing Polymorphonuclear MDSC Apoptosis and Monocytic MDSC Differentiation to APC in Cancer
Sabrin Albeituni,Chuanlin Ding,Min Liu,Xiaoling Hu,Fengling Luo,Goetz Kloecker,Michael Bousamra,Huang-Ge Zhang,Jun Yan +8 more
TL;DR: Yeast-derived whole β-glucan particles (WGP; a ligand to engage and activate dectin-1, oral treatment in vivo) significantly decreased tumor weight and splenomegaly in tumor-bearing mice with reduced accumulation of polymorphonuclear MDSC but not monocytic M DSC, and data indicate that WGP may be a potent immune modulator of M-MDSC suppressive function and differentiation in cancer.