Xiaoli Yang
Nanjing University
7 Papers
Xiaoli Yang is an academic researcher from Nanjing University. The author has contributed to research in topics: Cancer cell & Embryonic stem cell. The author has an hindex of 3, co-authored 6 publications.
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Papers
Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells.
Zan Zhang,Anhua Lei,Liyang Xu,Lu Chen,Yonglong Chen,Xuena Zhang,Yan Gao,Xiaoli Yang,Min Zhang,Ying Cao +9 more
TL;DR: It is shown that inhibition of the epigenetic modification enzyme enhancer of zeste homolog 2 (EZH2), histone deacetylases 1 and 3, lysine demethylase 1A (LSD1), or DNA methyltransferase 1 (DNMT1), which all promote cancer development and progression, leads to postmitotic neuron-like differentiation with loss of malignant features in distinct solid cancer cell lines.
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Coordinated regulation of the ribosome and proteasome by PRMT1 in the maintenance of neural stemness in cancer cells and neural stem cells
TL;DR: This paper showed that loss of neural stemness in cancer or neural stem cells via muscle-like differentiation or neuronal differentiation, respectively, caused downregulation of ribosome and proteasome components and major epigenetic factors, including PRMT1, EZH2, and LSD1.
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Regioselective Difunctionalization of Alkene: A Simple Access to Haloether, Haloesters and Halohydrins
Yuye Bai,Ya Zhuo Li,Ziyi Zhang,Xiaoli Yang,Jingwen Zhang,Lu Chen,Yi-Bing Li,Xianghua Zeng,Min Zhang +8 more
TL;DR: In this article , a protocol to generalize regioselective 1,2-difunctionalization of alkenes was proposed, which is a simple and efficient method for the preparation of haloethers, haloesters and halohydrins using alcohol as nucleophiles with inexpensive and commercially available N-halosuccinimide (NXS) as the halogenating reagent with low catalyst loading under mild reaction condition.
6
Coordinated regulation of ribosomes and proteasomes by PRMT1 in the maintenance of neural stemness of cancer cells and neural stem cells
TL;DR: It is shown that loss of neural stemness in cancer cells or neural stem cells leads to simultaneous down regulation of components of ribosomes and proteasomes, which are responsible for protein synthesis and degradation, respectively, and downregulation of major epigenetic factors.
Suppression of Cell Tumorigenicity by Non-neural Pro-differentiation Factors via Inhibition of Neural Property in Tumorigenic Cells.
TL;DR: In this paper, the authors showed that non-neural pro-differentiation factors, such as GATA3, HNF4A, HHEX, and FOXA3 suppress tumorigenicity via repression of neural stemness and promotion of nonneural property in tumorigenic cells.