Xiaoli Wang
Chinese Academy of Sciences
11 Papers
109 Citations
Xiaoli Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Fluorescence spectrometry & DNA. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of Xiaoli Wang include Beijing Institute of Genomics & University of Alberta.
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Papers
Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism
Bailin Zhao,Ying Yang,Xiaoli Wang,Zechen Chong,Ruichuan Yin,Shuhui Song,Chao Zhao,Cuiping Li,Hua Huang,Bao-Fa Sun,Danni Wu,Kang Xuan Jin,Maoyong Song,Ben-Zhan Zhu,Guibin Jiang,Jannie M. Rendtlew Danielsen,Guoliang Xu,Yun-Gui Yang,Hailin Wang +18 more
TL;DR: Redox-active quinones, a ubiquitous class of chemicals found in natural products, cancer therapeutics and environment, stimulate the conversion of 5mC to 5hmC in vivo, and increase 5hm C in 5751 genes in cells, suggesting an iron-regulated Tet-dependent DNA demethylation mechanism mediated by redox- active biomolecules.
Size-dependent toxicity of nano-C60 aggregates: more sensitive indication by apoptosis-related Bax translocation in cultured human cells.
TL;DR: It is found that nC(60) NPs with smaller size may have higher toxicity potency and can be indicated by apoptosis-related fluorescent protein fused Bax translocation at 20-times lower and noncytotoxic doses.
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Ultra-performance liquid chromatography/tandem mass spectrometry for accurate quantification of global DNA methylation in human sperms.
TL;DR: Clinical application of UPLC-MS/MS method in global DNA methylation detection of human sperms will be useful in human sperm quality evaluation and the study of epigenetic mechanisms responsible for male infertility.
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Quantum dots enhanced ultrasensitive detection of DNA adducts.
TL;DR: It is demonstrated that quantum dots can greatly improve the ultrasensitive capillary electrophoresis-laser induced fluorescence immunoassay of trace anti-benzo(a)pyrene diol epoxide (BPDE)-DNA adducts from sensitivity to separation and shows promising applications of QD in various DNA analyses, including DNA damage.
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Ultra-performance liquid chromatography-tandem mass spectrometry for rapid and highly sensitive analysis of stereoisomers of benzo[a]pyrene diol epoxide-DNA adducts.
TL;DR: An ultra-performance liquid chromatography tandem mass spectrometry with multiple reaction monitoring method (UPLC-MRM/MS) is developed for fast and sensitive analysis of four genotoxic stereoisomers of anti-benzo[a]pyrene diol epoxide (BPDE)-N(2)dG adducts, suggesting that a number of key optical intermediates are formed during activation of B,[a]P in A549 cells.
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