Xiaolan Lian
Beth Israel Deaconess Medical Center
11 Papers
19 Citations
Xiaolan Lian is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: PIN1 & Cancer. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Xiaolan Lian include Broad Institute & Fujian Medical University.
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Papers
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
Shingo Kozono,Yu-Min Lin,Hyuk-Soo Seo,Benika J. Pinch,Xiaolan Lian,Chenxi Qiu,Chenxi Qiu,Megan K. Herbert,Chun-Hau Chen,Li Tan,Ziang Jeff Gao,Walter Massefski,Zainab M. Doctor,Brian P. Jackson,Yuanzhong Chen,Sirano Dhe-Paganon,Kun Ping Lu,Xiao Zhen Zhou,Xiao Zhen Zhou +18 more
TL;DR: It is shown that this combination has potent anticancer activity in triple negative breast cancer by cooperatively targeting Pin1, a master regulator of oncogenic signaling networks, to eliminate cancer stem cells.
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Christian Dubiella,Benika J. Pinch,Kazuhiro Koikawa,Kazuhiro Koikawa,Daniel Zaidman,Evon Poon,Theresa D. Manz,Theresa D. Manz,Behnam Nabet,Shuning He,Efrat Resnick,Adi Rogel,Ellen M. Langer,Colin J. Daniel,Hyuk-Soo Seo,Ying Chen,Guillaume Adelmant,Shabnam Sharifzadeh,Scott B. Ficarro,Yann Jamin,Barbara Martins da Costa,Mark W. Zimmerman,Xiaolan Lian,Xiaolan Lian,Shin Kibe,Shin Kibe,Shingo Kozono,Shingo Kozono,Zainab M. Doctor,Christopher M. Browne,Christopher M. Browne,Annan Yang,Liat Stoler-Barak,Richa B. Shah,Nicholas E. Vangos,Ezekiel A. Geffken,Roni Oren,Eriko Koide,Samuel Sidi,Ziv Shulman,Chu Wang,Jarrod A. Marto,Sirano Dhe-Paganon,Thomas Look,Thomas Look,Xiao Zhen Zhou,Xiao Zhen Zhou,Kun Ping Lu,Kun Ping Lu,Rosalie C. Sears,Louis Chesler,Nathanael S. Gray,Nathanael S. Gray,Nir London +53 more
TL;DR: Sulfopin this article, a nanomolar Pin1 inhibitor, was developed to identify covalent inhibitors targeting Pin1's active site Cys113, which achieved potent cellular and in vivo target engagement and phenocopies Pin1 genetic knockout.
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Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.
Xiaolan Lian,Xiaolan Lian,Yu-Min Lin,Shingo Kozono,Megan K. Herbert,Xin Li,Xiaohong Yuan,Jiangrui Guo,Yafei Guo,Min Tang,Jia Lin,Yiping Huang,Bixin Wang,Chenxi Qiu,Cheng-Yu Tsai,Jane Xie,Ziang Jeff Gao,Yong Wu,Hekun Liu,Xiao Zhen Zhou,Xiao Zhen Zhou,Kun Ping Lu,Kun Ping Lu,Yuanzhong Chen +23 more
TL;DR: It is found that Pin1 mRNA and protein was significantly increased in both de novo leukemia clinical samples and multiple leukemia cell lines, compared with healthy controls and is a promising therapeutic target to block multiple cancer-driving pathways in AML.
Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growthin vivo
Christian Dubiella,Benika J. Pinch,Daniel Zaidman,Trevor Manz,Trevor Manz,Evon Poon,Shijie He,Efrat Resnick,Ellen M. Langer,Colin J. Daniel,Hyuk-Soo Seo,Yu-Hong Chen,Scott B. Ficarro,Yann Jamin,Xiaolan Lian,Xiaolan Lian,Shin Kibe,Shin Kibe,Shingo Kozono,Shingo Kozono,Kazuhiro Koikawa,Kazuhiro Koikawa,Zm,Behnam Nabet,Christopher M. Browne,Anli Yang,Liat Stoler-Barak,Richa B. Shah,Nicholas E. Vangos,Ezekiel A. Geffken,Roni Oren,Samuel Sidi,Ziv Shulman,Chunhui Wang,Jarrod A. Marto,Sirano Dhe-Paganon,Thomas Look,Thomas Look,Xiao Zhou,Xiao Zhou,Kun Ping Lu,Kun Ping Lu,Rosalie C. Sears,Louis Chesler,Nathaniel Gray,Nir London +45 more
TL;DR: Sulfopin is a suitable chemical probe for assessing Pin1-dependent pharmacology in cells and in vivo and indicates that Pin1 should be further investigated as a potential cancer target.
Correction to: Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.
Xiaolan Lian,Yu-Min Lin,Shingo Kozono,Megan K. Herbert,Xin Li,Xiaohong Yuan,Jiangrui Guo,Yafei Guo,Min Tang,Jia Lin,Yiping Huang,Bixin Wang,Chenxi Qiu,Cheng-Yu Tsai,Jane Xie,Ziang Jeff Gao,Yong Wu,Hekun Liu,Xiao Zhen Zhou,Xiao Zhen Zhou,Kun Ping Lu,Kun Ping Lu,Yuanzhong Chen +22 more
TL;DR: The original article [1] contained minor typesetting errors affecting the following authors: Ziang Jeff Gao, Xiao Zhen Zhou, and Kun Ping Lu.