8 Papers
Xiaolan Hu is an academic researcher from Macau University of Science and Technology. The author has contributed to research in topics: Chemistry & Drug. The author has an hindex of 1, co-authored 4 publications.
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Papers
Stand out from matrix: Ultra-sensitive LC-MS/MS method for determination of histamine in complex biological samples using derivatization and solid phase extraction.
TL;DR: An ultra-sensitive and accurate LC-MS/MS quantification method based on derivatization, isotope dilution, and solid phase extraction was developed and successfully applied for the quantification of histamine in clinical serum samples of asthma patients and mast cell treated with chemicals modulating histamine release.
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Covalent Protein Modification: An Unignorable Factor for Bisphenol A-Induced Hepatotoxicity.
TL;DR: The results revealed that the covalent protein modification is an unignorable factor for BPA hepatotoxicity and the workflow can be applied to identify protein adducts of other emerging contaminants and possible risk.
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Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS.
TL;DR: In this paper, an affinity ultrafiltration with drug targets of interest coupled with high-performance liquid chromatography-mass spectrometry (AUF-HPLC-MS/MS) was used to quickly screen out bioactive constituents as ligands against target enzymes from complex extracts of W. ugandensis.
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Quantification of Osimertinib and Metabolite-Protein Modification Reveals Its High Potency and Long Duration of Effects on Target Organs.
TL;DR: In this article, a simple, selective, and sensitive liquid chromatography-mass spectrometry (LC-MS)/MS quantitative method was established based on the mechanism of a drug and its metabolite-protein adducts using osimertinib as an example.
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Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics
TL;DR: Recent progress in the systematic discovery of DMPCs using shotguns proteomics is reviewed and the applications of shotgun proteomics supporting drug development, toxicity mechanism investigation, and drug repurposing processes are reviewed and prospected.
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