Xiaojun Wu
Pennington Biomedical Research Center
23 Papers
202 Citations
Xiaojun Wu is an academic researcher from Pennington Biomedical Research Center. The author has contributed to research in topics: Leptin & Leptin receptor. The author has an hindex of 15, co-authored 22 publications. Previous affiliations of Xiaojun Wu include Shanghai University & Louisiana State University System.
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Papers
Astrocytes Modulate Distribution and Neuronal Signaling of Leptin in the Hypothalamus of Obese Avy Mice
TL;DR: It is concluded that inhibition of astrocytic activity resulted in enhanced neuronal leptin uptake and signaling in the Avy mouse with adult-onset obesity.
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IL-15 Receptor Deletion Results in Circadian Changes of Locomotor and Metabolic Activity
Yi He,Xiaojun Wu,Reas S. Khan,Abba J. Kastin,Germaine G Cornelissen-Guillaume,Hung Hsuchou,Barry Robert,Franz Halberg,Weihong Pan +8 more
TL;DR: Activation of hypothalamic neurons by IL-15 in mice contributes to thermoregulation and modifies the metabolic phenotype, and the difference in the dark and light phases suggests thatIL-15Rα participates in circadian rhythm regulation.
Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis
TL;DR: IL15 improves this CNS autoimmune disorder as a potential therapeutic agent and reduces EAE severity by upregulation of IL15Ralpha mRNA in different regions of the brain and spinal cord.
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Unique leptin trafficking by a tailless receptor
TL;DR: Surprisingly, ObR860, a construct with no cytoplasmic sequence, could act like the classical ObRa transporter in internalizing leptin, and this novel finding may have significant implications for leptin transport.
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Melanocortin potentiates leptin-induced STAT3 signaling via MAPK pathway.
TL;DR: The co‐existence of receptors for leptin and melanocortin in cerebral microvessels suggests possible interactions between leptin and α‐melanocyte stimulating hormone (MSH) signaling and the cooperation of ObRb and G protein‐coupled receptors in cellular signaling.
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