Xiaojuan Lu
Chinese Academy of Sciences
9 Papers
5 Citations
Xiaojuan Lu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: RIPK1 & Necroptosis. The author has an hindex of 5, co-authored 8 publications.
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Papers
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Zheming Wu,Yang Geng,Xiaojuan Lu,Yuying Shi,Guowei Wu,Mengmeng Zhang,Bing Shan,Heling Pan,Junying Yuan +8 more
TL;DR: This study identified 2-amino-5-chloro-N,3-dimethylbenzamide (CDDO), a compound known to inhibit heat shock protein 90 (HSP90), as an inhibitor of necroptosis that could also inhibit ferroptosis, and found that HSP90 defined a common regulatory nodal between necroPTosis and ferroPTosis.
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Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression.
Kezhou Zhu,Wei Liang,Zaijun Ma,Daichao Xu,Shuangyi Cao,Xiaojuan Lu,Nan Liu,Bing Shan,Lihui Qian,Junying Yuan,Junying Yuan +10 more
TL;DR: It is concluded that TNFα-induced necroptosis signaling events mediated by RIPK1 and RIPK3 activation, in addition to the MLKL oligomerization, promotes the expression of cytokines involving multiple intracellular signaling mechanisms including NF-κB pathway and p38.
USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1.
Daichao Xu,Bing Shan,Huawang Sun,Juan Xiao,Kezhou Zhu,Xingxing Xie,Xingyan Li,Wei Liang,Xiaojuan Lu,Lihui Qian,Junying Yuan +10 more
TL;DR: This study suggests that Akt-regulated USP14 activity modulates both proteasomal degradation and autophagy through controlling K48 and K63 ubiquitination, respectively.
Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners
Xingyan Li,Mengmeng Zhang,Xinyue Huang,Wei Liang,Ganquan Li,Xiaojuan Lu,Yanxia Li,Heling Pan,Linyu Shi,Hong Zhu,Lihui Qian,Bing Shan,Junying Yuan +12 more
TL;DR: This study demonstrates the distinct roles of K612 ubiquitination in mRIPK1/K627 ubiquitinations in hRIPK 1 in regulating its pro-death kinase activity in response to TNFα and pro-survival activity in Response to TLRs signaling.
Bilateral linear SURE-based SAR interferogram filter
TL;DR: In this article, a new filter for interferometric synthetic aperture radar (InSAR) phase denoising is proposed, which preserves texture details and improves the performance of phase filtering.
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