Xiaojing Yu
Novartis
7 Papers
Xiaojing Yu is an academic researcher from Novartis. The author has contributed to research in topics: Medicine & Psoriasis. The author has an hindex of 1, co-authored 1 publications.
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Papers
IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis.
James G. Krueger,Keith A. Wharton,Thomas Schlitt,Maria Suprun,Rebecca I. Torene,Xiaoyu Jiang,Claire Q.F. Wang,Judilyn Fuentes-Duculan,Nicole Hartmann,Thomas Peters,Irina Koroleva,Rainer Hillenbrand,Martin Letzkus,Xiaojing Yu,Yue Li,Anton Glueck,Anke Hasselberg,Brian Flannery,Mayte Suárez-Fariñas,Wolfgang Hueber +19 more
TL;DR: The data suggest that IL-17A is the critical node within multidimensional pathogenic immune circuits that maintain psoriasis plaques, and that early reduction of IL- 17A-dependent feed-forward transcripts synthesized by hyperplastic keratinocytes favors plaque resolution.
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ILF2 Contributes to Hyperproliferation of Keratinocytes and Skin Inflammation in a KLHDC7B-DT-Dependent Manner in Psoriasis
X H Yin,Zhenyu Yang,Mingsheng Zhu,Cheng Chen,Sha Huang,Hua Zhong,H Wen,Qing Sun,Xiaojing Yu,Jianjun Yan +9 more
TL;DR: ILF2 and KLHDC7B-DT are involved in the hyperproliferation of keratinocytes and skin inflammation in psoriasis and functions in a KLH DC7 B-DT-dependent manner.
Spatial transcriptomics reveals heterogeneity of macrophages in the tumor microenvironment of granulomatous slack skin
Yawei Feng,Shiguan Wang,Jianjun Xie,B. Ding,Min Wang,Feng Zhang,Ping Mi,Chunxu Hai Xin Wang,Ruirui Liu,Tingguo Zhang,Xiaojing Yu,Detian Yuan,Cuijuan Zhang +12 more
TL;DR: Light is shed on the characteristics of macrophages in the GSS microenvironment and a theoretical basis for the application of MMP9 inhibitors to prevent cutaneous relaxation of GSS is provided.
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Downregulation of MAL2 inhibits breast cancer progression through regulating β-catenin/c-Myc axis
TL;DR: Investigating the role of MAL2 in breast cancer (BC) provided evidence that MAL2 acted as a potential tumor promoter by regulating EMT and β-catenin/c-Myc axis, suggesting potential implications for anti-metastatic therapy for BC.
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Methyl-CpG binding protein 2 is associated with the prognosis and mortality of elderly patients with hip fractures
Xuejian Gao,Shanshan Xue,Fuqiang Yang,Baoling Wu,Xiaojing Yu,Baoquan An +5 more
TL;DR: In this paper , the expression level and clinical significance of Methyl-CpG binding Protein 2 (MECP2) in elderly patients with hip fractures were investigated, and the results showed that patients with higher MECP 2 predicted higher dynamic Harris scores, lower postoperative complications, lower 1-year mortality, and higher BI scores.
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