Xiaojing Chen
Wenzhou Medical College
9 Papers
3 Citations
Xiaojing Chen is an academic researcher from Wenzhou Medical College. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 2, co-authored 6 publications.
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Papers
Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI).
Jianchang Qian,Xianxin Chen,Sheng Shu,Wenxin Zhang,Bo Fang,Xiaojing Chen,Yunjie Zhao,Zhiguo Liu,Guang Liang +8 more
TL;DR: A new series of curcumin analogs are presented as promising anti-inflammatory agents for treatment of ALI and markedly alleviated lipopolysaccharides (LPS)-induced acute lung injury.
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Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage
Ding-fang Zhang,Zhi-chun Yang,Jian-qiang Chen,Xiangxiang Jin,Yin-da Qiu,Xiaojing Chen,Hong-yi Shi,Zhiguo Liu,Min-shan Wang,Min-shan Wang,Guang Liang,Xiaohui Zheng +11 more
- 06 Jul 2021
TL;DR: In this paper, the effect of Piperlongumine (PL) on DNA damage and repair in prostate cancer cells was investigated by using immunofluorescence (IF) and comet assay.
Discovery of novel and selective SIK2 inhibitors by the application of AlphaFold structures and generative models.
Meifang Zhu,Qi Li,F. Gao,Tingting Liu,Xiaojing Chen,Man Zhang,Alexander Aliper,Fengzhi Ren,Xiao Ding,Alex Zhavoronkov +9 more
TL;DR: Based on the binding pose of the reported compound with AlphaFold protein structure, a series of hinge cores were generated via AI-generative models and led to the discovery of compound 8g with superior potency against SIK2 compared with the reported inhibitors.
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Synthesis and Anti-inflammatory Evaluation of (R)-, (S)-, and (±)-Sanjuanolide Isolated from Dalea frutescens
Bo Fang,Zhongxiang Xiao,Yinda Qiu,Sheng Shu,Xianxin Chen,Xiaojing Chen,Fei Zhuang,Yunjie Zhao,Guang Liang,Zhiguo Liu +9 more
TL;DR: This study presents a convergent strategy for the first total synthesis of ( R)-, ( S)-, and (±)-sanjuanolide (1), confirmed as promising new leads for developing anti-inflammatory agents.
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cyy260 suppresses the proliferation, migration and tumor growth of osteosarcoma by targeting PDGFR-β signaling pathway.
Yinda Qiu,Hao Yang,Ruiling Zheng,Xiaojing Chen,Yi Wang,Qi Yan,Yanfei Ye,Jianxia Zhang,H Y Han,Kun Wang,Yunjie Zhao,Lehao Huang,Xiaokun Li,Zhiguo Liu +13 more
TL;DR: Zhang et al. as mentioned in this paper investigated the antitumor effect and underlying mechanism of cyy260 in osteosarcoma via suppressing PDGFR-β and its downstream pathway.
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