Xiaojing Chen
Max Delbrück Center for Molecular Medicine
8 Papers
6 Citations
Xiaojing Chen is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Xiaojing Chen include Charité.
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Papers
High-throughput identification of antigen-specific TCRs by TCR gene capture
Carsten Linnemann,Bianca Heemskerk,Pia Kvistborg,Roelof J.C. Kluin,Dmitriy A. Bolotin,Xiaojing Chen,Kaspar Bresser,Marja Nieuwland,Remko Schotte,Samira Michels,Raquel Gomez-Eerland,Lorenz Jahn,Pleun Hombrink,Nicolas Legrand,Chengyi Jenny Shu,Ilgar Z. Mamedov,Arno Velds,Christian U. Blank,John B. A. G. Haanen,Maria A. Turchaninova,Ron M. Kerkhoven,Hergen Spits,Sine Reker Hadrup,Mirjam H.M. Heemskerk,Thomas Blankenstein,Dmitriy M. Chudakov,Gavin M. Bendle,Ton N. Schumacher +27 more
TL;DR: The ability to identify tumor-reactive TCRs within intratumoral T cell subsets without knowledge of antigen specificities is demonstrated, which may be the first step toward the development of autologous TCR gene therapy to target patient-specific neoantigens in human cancer.
201
Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.
TL;DR: The data, which demonstrate human TCR–MHC coevolution after divergence from rodents, explain the greater T cell diversity in humans and suggest a mechanism for ensuring that any V–J gene combination can be selected by a single MHC II.
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Ultrafast PCR Detection of COVID-19 by Using a Microfluidic Chip-Based System
Xiaojing Chen,Yiteng Liu,Xuan-lin Zhan,Yibo Gao,Zhongyi Sun,Weijia Wen,Weidong Zheng +6 more
TL;DR: A microchip-based ultrafast PCR system called SWM-02, proposed to make PCR assay in a rapid, portable, and low-cost strategy, has the capability of offering timely and sensitive on-site molecular diagnosis for prevention and control of pathogen transmission.
Patent
Combined t cell receptor gene therapy of cancer against mhc i and mhc ii-restricted epitopes of the tumor antigen ny-eso-1
Thomas Blankenstein,Lucia Poncette,Xiaojing Chen +2 more
- 11 Mar 2016
TL;DR: In this article, the authors proposed a T cell receptor (TCR) gene therapy for cancer using adoptive T cell therapy, in which the TCR alpha chain and/or TCR beta chain constructs are encoded in a nucleic acid.
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Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma
Carlotta Welters,Maria Fernanda Lammoglia Cobo,Christian A. Stein,Meng-Tung Hsu,Amin Ben Hamza,Livius Penter,Xiaojing Chen,Christopher Buccitelli,Oliver Popp,Philipp Mertins,Kerstin Dietze,Lars Bullinger,Andreas Moosmann,Eric Blanc,Dieter Beule,Armin Gerbitz,Julia Strobel,Holger Hackstein,Hans-Peter Rahn,Klaus Dornmair,Thomas Blankenstein,Leo Hansmann +21 more
TL;DR: It is shown that dominant bone marrow T-cell clones in treatment naïve patients rarely recognize antigens presented on multiple myeloma cells and exhibit low expression of classical immune checkpoint molecules.
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